ArticleMolecular and cellular biology1998
The Rho family G proteins play a critical role in muscle differentiation.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
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- Growth hormone-releasing peptide-biotin conjugate stimulates myocytes differentiation through insulin-like growth factor-1 and collagen type I.BMB reports · 2015Article
- CEP2 attenuates myoblast differentiation but does not affect proliferation.International journal of biological sciences · 2015Article
- The STARS signaling pathway: a key regulator of skeletal muscle function.Pflugers Archiv : European journal of physiology · 2014Review
- ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets.Frontiers in neuroscience · 2014Review
- Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?PloS one · 2014Article
- Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells.BMC cell biology · 2013Article
- MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1 gene.The Journal of biological chemistry · 2012Article
- Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.BMC medicine · 2012Article
- Activation of RhoA in podocytes induces focal segmental glomerulosclerosis.Journal of the American Society of Nephrology : JASN · 2011Article
- Beta3-integrin mediates satellite cell differentiation in regenerating mouse muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Rho family GTP-binding proteins play a critical role in a variety of cytoskeleton-dependent cell functions. In this study, we examined the role of Rho family G proteins in muscle differentiation. Dominant negative forms of Rho family proteins and RhoGDI, a GDP dissociation inhibitor, suppressed transcription of muscle-specific genes, while mutationally activated forms of Rho family proteins strongly activated their transcription. C2C12 cells overexpressing RhoGDI (C2C12RhoGDI cells) did not differentiate into myotubes, and expression levels of myogenin, MRF4, and contractile protein genes but not MyoD and myf5 genes were markedly reduced in C2C12RhoGDI cells. The promoter activity of the myogenin gene was suppressed by dominant negative mutants of Rho family proteins and was reduced in C2C12RhoGDI cells. Expression of myocyte enhancer binding factor 2 (MEF2), which has been reported to be required for the expression of the myogenin gene, was reduced at the mRNA and protein levels in C2C12RhoGDI cells. These results suggest that the Rho family proteins play a critical role in muscle differentiation, possibly by regulating the expression of the myogenin and MEF2 genes.
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