ArticleMolecular and cellular biology1998
The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 96 citations in OpenAlex.
- Polyamine Induction of Secondary Metabolite Biosynthetic Genes in Fungi Is Mediated by Global Regulator LaeA and α-NAC Transcriptional Coactivator: Connection to Epigenetic Modification of Histones.Molecules (Basel, Switzerland) · 2025Review
- Identifying Methylation Signatures and Rules for COVID-19 With Machine Learning Methods.Frontiers in molecular biosciences · 2022Article
- Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum.International journal of molecular sciences · 2021Review
- Lnc-GD2H Promotes Proliferation by Forming a Feedback Loop With c-Myc and Enhances Differentiation Through Interacting With NACA to Upregulate Myog in C2C12 Myoblasts.Frontiers in cell and developmental biology · 2021Article
- The beta Subunit of Nascent Polypeptide Associated Complex Plays A Role in Flowers and Siliques Development ofInternational journal of molecular sciences · 2020Article
- Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.The Journal of biological chemistry · 2019Article
- Article
- NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation.Nature communications · 2015Article
- A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells.PloS one · 2015Article
- αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.Cell death & disease · 2014Article
- Cytokine effects induced by the human autoallergen α-NAC.The Journal of investigative dermatology · 2014Article
- The nascent polypeptide-associated complex is a key regulator of proteostasis.The EMBO journal · 2013Article
- Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription.Journal of molecular biology · 2013Article
- An inducible expression system to measure rhodopsin transport in transgenic Xenopus rod outer segments.PloS one · 2013Article
- Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome.The Journal of biological chemistry · 2010Article
- Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit.Protein & cell · 2010Article
- Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo.Molecular and cellular biology · 2010Article
- Characterisation of the nascent polypeptide-associated complex in fission yeast.Molecular biology reports · 2007Article
- Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells.Molecular and cellular biochemistry · 2007Article
- Inhibition of alpha nascent polypeptide associated complex protein may induce proliferation, differentiation and enhance the cytotoxic activity of human CD8+ T cells.Journal of clinical immunology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the characterization of clone 1.9.2, a gene expressed in mineralizing osteoblasts. Remarkably, clone 1.9.2 is the murine homolog of the alpha chain of the nascent polypeptide-associated complex (alpha-NAC). Based on sequence similarities between alpha-NAC/1.9.2 and transcriptional regulatory proteins and the fact that the heterodimerization partner of alpha-NAC was identified as the transcription factor BTF3b (B. Wiedmann, H. Sakai, T. A. Davis, and M. Wiedmann, Nature 370:434-440, 1994), we investigated a putative role for alpha-NAC/ 1.9.2 in transcriptional control. The alpha-NAC/1.9.2 protein potentiated by 10-fold the activity of the chimeric activator GAL4/VP-16 in vivo. The potentiation was shown to be mediated at the level of gene transcription, because alpha-NAC/1.9.2 increased GAL4/VP-16-mediated mRNA synthesis without affecting the half-life of the GAL4/VP-16 fusion protein. Moreover, the interaction of alpha-NAC/1.9.2 with a transcriptionally defective mutant of GAL4/VP-16 was severely compromised. Specific protein-protein interactions between alpha-NAC/1.9.2 and GAL4/VP-16 were demonstrated by gel retardation, affinity chromatography, and protein blotting assays, while interactions with TATA box-binding protein (TBP) were detected by immunoprecipitation, affinity chromatography, and protein blotting assays. Based on these interactions that define the coactivator class of proteins, we conclude that the alapha-NAC/1.9.2 gene product functions as a transcriptional coactivator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.