ArticleInfection and immunity1998
Human platelets damage Aspergillus fumigatus hyphae and may supplement killing by neutrophils.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan.PLoS pathogens · 2024Article
- Invasive Pulmonary Aspergillosis in Patients with and without SARS-CoV-2 Infection.Journal of fungi (Basel, Switzerland) · 2023Article
- Platelets: a potential role in chronic respiratory diseases?European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection.PLoS pathogens · 2020Article
- Galactosaminogalactan (GAG) and its multiple roles inVirulence · 2019Review
- Candida: Platelet Interaction and Platelet Activity in vitro.Journal of innate immunity · 2019Article
- Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus.PLoS pathogens · 2017Article
- First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis.Frontiers in microbiology · 2016Review
- Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis.Eukaryotic cell · 2015Article
- Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro.International journal of medical microbiology : IJMM · 2015Article
- Platelets: at the nexus of antimicrobial defence.Nature reviews. Microbiology · 2014Review
- Virulence and thrombocyte affectation of two Aspergillus terreus isolates differing in amphotericin B susceptibility.Medical microbiology and immunology · 2013Article
- Interaction of platelets and anidulafungin against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2013Article
- A mucormycosis case in a cirrhotic patient successfully treated with posaconazole and review of published literature.Mycopathologia · 2012Review
- Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis.Infection and immunity · 2010Article
- Innate immunity to Aspergillus species.Clinical microbiology reviews · 2009Review
- Potential antifungal effects of human platelets against zygomycetes in vitro.The Journal of infectious diseases · 2009Article
- Human platelets attenuate Aspergillus species via granule-dependent mechanisms.The Journal of infectious diseases · 2008Article
- Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.International journal of antimicrobial agents · 2007Article
- Infectious disease, the innate immune response, and fibrosis.The Journal of clinical investigation · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neutropenia is considered a significant risk factor for invasive aspergillosis but is almost always associated with concurrent thrombocytopenia. Studies determined that platelets, like neutrophils, attached to cell walls of the invasive hyphal form of Aspergillus fumigatus. Organisms were damaged as shown by loss of cell wall integrity in scanning laser confocal microscopy and release of defined hyphal surface glycoproteins. Rapid expression appearance of surface antigen CD63 and release of markers of platelet degranulation confirmed activation during attachment to hyphae. Optimal platelet activation required opsonization of hyphae with fresh or heat-inactivated whole plasma. These effects of opsonization with whole plasma could not be duplicated by pooled human serum, immunoglobulin G, or fibrinogen, whether used separately or combined. Thus, platelets in the presence of whole plasma have the potential to play an important role in normal host defenses against invasive aspergillosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.