ArticleMolecular biology of the cell1998
Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Inhibition of MRN activity by a telomere protein motif.Nature communications · 2021Article
- Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.PLoS genetics · 2016Article
- Regulatory motifs in Chk1.Cell cycle (Georgetown, Tex.) · 2013Article
- Identification of two telomere-proximal fission yeast DNA replication origins constrained by nearby cis-acting sequences to replicate in late S phase.F1000Research · 2012Article
- Computational analysis of DNA replicases in double-stranded DNA viruses: relationship with the genome size.Nucleic acids research · 2011Article
- Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.Cell cycle (Georgetown, Tex.) · 2010Article
- To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Frontiers in bioscience (Landmark edition) · 2010Review
- ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.The Journal of cell biology · 2010Article
- Protection and replication of telomeres in fission yeast.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2009Review
- Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.Genes & development · 2008Article
- DNA damage response at functional and dysfunctional telomeres.Genes & development · 2008Review
- The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.Genetics · 2007Article
- Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair.Molecular and cellular biology · 2006Article
- trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.PLoS genetics · 2006Article
- Limited TTP supply affects telomere length regulation in a telomerase-independent fashion.Nucleic acids research · 2005Article
- Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.Eukaryotic cell · 2005Article
- Replication proteins influence the maintenance of telomere length and telomerase protein stability.Molecular and cellular biology · 2003Article
- Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.Genetics · 2002Article
- Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases.Molecular biology of the cell · 2002Article
- ATM function and telomere stability.Oncogene · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied telomere length in Schizosaccharomyces pombe strains carrying mutations affecting cell cycle checkpoints, DNA repair, and regulation of the Cdc2 protein kinase. Telomere shortening was found in rad1, rad3, rad17, and rad26 mutants. Telomere lengths in previously characterized rad1 mutants paralleled the replication checkpoint proficiency of those mutants. In contrast, rad9, chk1, hus1, and cds1 mutants had intact telomeres. No difference in telomere length was seen in mutants affected in the regulation of Cdc2, whereas some of the DNA repair mutants examined had slightly longer telomeres than did the wild type. Overexpression of the rad1(+) gene caused telomeres to elongate slightly. The kinetics of telomere shortening was monitored by following telomere length after disruption of the rad1(+) gene; the rate was approximately 1 nucleotide per generation. Wild-type telomere length could be restored by reintroduction of the wild-type rad1(+) gene. Expression of the Saccharomyces cerevisiae RCK1 protein kinase gene, which suppresses the radiation and hydroxyurea sensitivity of Sz. pombe checkpoint mutants, was able to attenuate telomere shortening in rad1 mutant cells and to increase telomere length in a wild-type background. The functional effects of telomere shortening in rad1 mutants were assayed by measuring loss of a linear and a circular minichromosome. A minor increase in loss rate was seen with the linear minichromosome, and an even smaller difference compared with wild-type was detected with the circular plasmid.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.