ArticleMolecular biology of the cell1998
DdLIM is a cytoskeleton-associated protein involved in the protrusion of lamellipodia in Dictyostelium.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- From Molecules to Amoeboid Movement: A New Way for Understanding the Morphology Through Actin-Binding Proteins.Biomolecules · 2024Article
- V-1 regulates capping protein activity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Geometry-Driven Polarity in Motile Amoeboid Cells.PloS one · 2014Article
- Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses.Journal of cell science · 2013Article
- Ndm, a coiled-coil domain protein that suppresses macropinocytosis and has effects on cell migration.Molecular biology of the cell · 2012Article
- Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells.Journal of muscle research and cell motility · 2012Article
- Local motion analysis reveals impact of the dynamic cytoskeleton on intracellular subdiffusion.Biophysical journal · 2012Article
- A genome-wide over-expression screen identifies genes involved in phagocytosis in the human protozoan parasite, Entamoeba histolytica.PloS one · 2012Article
- Chemotactic cell trapping in controlled alternating gradient fields.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Tropomyosin dynamics in cardiac thin filaments: a multisite forster resonance energy transfer and anisotropy study.Biophysical journal · 2008Article
- Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation.Biophysical journal · 2008Article
- EhLimA, a novel LIM protein, localizes to the plasma membrane in Entamoeba histolytica.Eukaryotic cell · 2007Article
- A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.The EMBO journal · 2005Article
- The PXL1 gene of Saccharomyces cerevisiae encodes a paxillin-like protein functioning in polarized cell growth.Molecular biology of the cell · 2004Article
- Functions of LIM proteins in cell polarity and chemotactic motility.The EMBO journal · 2002Article
- Hisactophilin is involved in osmoprotection in Dictyostelium.BMC biochemistry · 2002Article
- Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton.Molecular biology of the cell · 2002Article
- The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.Molecular biology of the cell · 2000Article
- Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein.Molecular biology of the cell · 1999Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DdLim, a multi-domain member of the cysteine-rich family of LIM domain proteins, was isolated from Dictyostelium cells where it localizes in lamellipodia and at sites of membrane ruffling. The transcription and expression of DdLim are developmentally regulated, and the timing of its increased association with the actin cytoskeleton coincides with the acquisition in starved cells of a motile, chemotactic behavior. Vegetative cells that overexpress DdLim contain large lamella and exhibit ruffling at the cortex. The high frequency of large, multinucleated mutant cells found in suspension culture suggests that excess DdLim interferes with cytokinesis. DdLim was also identified as a protein in a Dictyostelium cell lysate that associated indirectly, but in a guanosine triphosphate-dependent manner, with a GST-rac1 fusion protein. The data presented suggest that DdLim acts as an adapter protein at the cytoskeleton-membrane interface where it is involved in a receptor-mediated rac1-signaling pathway that leads to actin polymerization in lamellipodia and ultimately cell motility.
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