Trial reportClinical and experimental immunology1998
Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha (TNF-alpha) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL).
Trial report in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
- Brief research report: Repurposing pentoxifylline to treat intense acute swimming-Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms.Frontiers in pharmacology · 2022Article
- Editorial: The Role of Biomarkers in the Immunopathology and Diagnosis of Immune Exacerbations in Leprosy-New Frontiers to Manage This Neglected Disease.Frontiers in medicine · 2022Article
- Neutrophils in Leprosy.Frontiers in immunology · 2019Review
- Innate Immune Responses in Leprosy.Frontiers in immunology · 2018Review
- The Effects of Prednisolone Treatment on Cytokine Expression in Patients with Erythema Nodosum Leprosum Reactions.Frontiers in immunology · 2018Article
- Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.PLoS neglected tropical diseases · 2017Article
- A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.Frontiers in immunology · 2017Review
- Atorvastatin and trans-caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats.Molecular and clinical oncology · 2015Article
- Pentoxifylline and its applications in dermatology.Indian dermatology online journal · 2014Article
- Effect of TNF-α production inhibitors on the production of pro-inflammatory cytokines by peripheral blood mononuclear cells from HTLV-1-infected individuals.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2011Article
- Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview.Future microbiology · 2011Review
- Pentoxifylline decreases allodynia and hyperalgesia in a rat model of neuropathic pain.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
- High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.Infection and immunity · 2010Article
- [Anti-inflammatory effects of pentoxifylline: importance in cardiac surgery].Der Anaesthesist · 2009Review
- M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression.BMC microbiology · 2006Article
- The continuing challenges of leprosy.Clinical microbiology reviews · 2006Review
- Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.British journal of pharmacology · 2004Article
- IgG1 antimycobacterial antibodies can reverse the inhibitory effect of pentoxifylline on tumour necrosis factor alpha (TNF-alpha) secreted by mycobacterial antigen-stimulated adherent cells.Clinical and experimental immunology · 2004Article
- Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha.Immunology · 2003Article
- T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence has implicated TNF-alpha as a pivotal molecule involved in the systemic inflammatory manifestations of ENL, an acute inflammatory complication that may occur in the chronic course of leprosy. In the present study, the mechanism of action of pentoxifylline (PTX) as an alternative therapy for management of leprosy reactions has been evaluated. The effect of PTX on TNF-alpha production was examined in leprosy patients at the protein level and at the transcriptional level as well. Treatment of ENL patients with PTX (1200 mg daily) ameliorated the systemic symptoms and favoured the evolution of reactional leprosy lesions. Serum TNF-alpha was assayed before and during treatment with PTX in 15 patients. The increased TNF-alpha levels seen in the circulation during the reaction were dramatically reduced within 3-7 days of therapy. No significant effect on serum IL-6 was noted. In vitro TNF-alpha production was assayed upon culture stimulation with Mycobacterium leprae. A reduction of inducible TNF-alpha in peripheral blood mononuclear cells (PBMC) was seen after 1-2 weeks of in vivo administration of PTX. Furthermore, no effect of the drug on IL-10 secretion was detected in these cultures. A kinetic analysis of the expression of TNF-alpha and IL-6 mRNA at the site of leprosy lesion was performed in six reactional patients by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR). The amount of TNF-alpha mRNA was increased in the tissue during ENL compared with before the reaction, and decreased thereafter following treatment for reaction (either PTX or thalidomide). These data suggest that PTX inhibits TNF-alpha production in ENL patients both in vivo and in vitro, and it may be useful in the treatment of leprosy patients undergoing ENL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.