ArticleThe American journal of physiology1998
Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility.
Article in The American journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Excitatory effect of acotiamide on rat and human bladder: Implications for underactive bladder treatment.Life sciences · 2020Article
- The role of the mucosa in modulation of evoked responses in the spinal cord injured rat bladder.Neurourology and urodynamics · 2018Article
- Understanding overactive bladder and urgency incontinence: what does the brain have to do with it?F1000Research · 2018Review
- Measurement of smooth muscle function in the isolated tissue bath-applications to pharmacology research.Journal of visualized experiments : JoVE · 2015Article
- The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease.Current opinion in pharmacology · 2014Review
- Changes in nerve-mediated contractility of the lower urinary tract in a mouse model of premature ageing.British journal of pharmacology · 2014Article
- Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder.Brain research bulletin · 2008Article
- Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction.British journal of pharmacology · 2006Review
- Muscarinic receptor transcript and protein density in hypertrophied and atrophied rat urinary bladder.Neurourology and urodynamics · 2006Article
- The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2004Article
- Quantitative analysis of the levels of expression of muscarinic receptor subtype RNA in the detrusor muscle of patients with overactive bladder.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2004Article
- Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2.American journal of physiology. Regulatory, integrative and comparative physiology · 2003Article
- Selective alkylation of rat urinary bladder muscarinic receptors with 4-DAMP mustard reveals a contractile function for the M2 muscarinic receptor.Journal of receptor and signal transduction research · 1999Article
- M2 receptors in genito-urinary smooth muscle pathology.Life sciences · 1999Article
- M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder.The American journal of physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractility of rat bladder were compared in vitro. Schild plot analysis of cumulative carbachol dose-response curves in the presence of antagonists was consistent with M3-mediated bladder contractions. However, nerve-evoked contractions were inhibited 15% at 30 Hz (P < 0.01) by 10 nM pirenzepine (M1-selective antagonist), whereas 10 nM methoctramine (M2-selective antagonist) increased these contractions by 17% at 30 Hz (P < 0.01). Identical doses had no effect on carbachol-induced contractions, indicating prejunctional M1 facilitory and M2 inhibitory receptors. m1 Receptors could not be identified by subtype-selective antibodies, nor could the m1 transcript be identified by Northern hybridization. However, m1, m2, m3, and m4 transcripts were identified in rat bladder using the reverse transcriptase-polymerase chain reaction, providing support for the existence of the m1 subtype. In conclusion, strong evidence is provided for the existence of prejunctional M1 facilitory and M2 inhibitory and postjunctional M3 receptors modulating contractility in the rat urinary bladder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.