ArticleThe British journal of ophthalmology1997
Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes.
Article in The British journal of ophthalmology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 106 citations in OpenAlex.
- Dexamethasone implant vs. anti-VEGF for diabetic macular edema with epiretinal membrane: short-term outcomes.International journal of retina and vitreous · 2026Article
- Impact of Aflibercept vs Dexamethasone Treatment on Epiretinal Membrane Formation in Eyes with Diabetic Macular Edema.Ophthalmology and therapy · 2024Article
- VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity.Diagnostics (Basel, Switzerland) · 2024Article
- Review
- Factors associated with diabetic macular edema in patients with proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Observational
- Epiretinal Membrane Peeling in Eyes with Retinal Vein Occlusion: Visual and Morphologic Outcomes.Ophthalmology and therapy · 2022Article
- Vitrectomy for diabetic macular edema and the relevance of external limiting membrane.BMC ophthalmology · 2021Article
- Comparison between Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Levels in Rhegmatogenous Retinal Detachment.Journal of ophthalmology · 2021Article
- Inflammatory and angiogenic biomarkers in diabetic retinopathy.Biochemia medica · 2020Review
- Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells.Experimental and therapeutic medicine · 2020Article
- Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development.Translational vision science & technology · 2020Review
- Evaluation of TGF-Beta 2 and VEGFJournal of ophthalmology · 2018Article
- Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes.Scientific reports · 2017Article
- Epiretinal membrane: optical coherence tomography-based diagnosis and classification.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- The Vitreomacular Interface in Diabetic Retinopathy.Journal of ophthalmology · 2015Review
- Diabetic Retinopathy: Vascular and Inflammatory Disease.Journal of diabetes research · 2015Review
- Reduced effect of anti-vascular endothelial growth factor agents on diabetics with vitreomacular interface abnormalities.International ophthalmology · 2014Article
- Intrasilicone oil injection of bevacizumab at the end of retinal reattachment surgery for severe proliferative vitreoretinopathy.Eye (London, England) · 2014Article
- Ranibizumab for idiopathic epiretinal membranes: A retrospective case series.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
AIMS/
backgroundEpiretinal membranes (ERMs) arise from a variety of causes or, in some cases, for unknown reasons. Once established, ERMs tend to progress, becoming more extensive and exerting increasing traction along the inner surface of the retina. One possible cause for their progression is the production of growth factors by cells within ERMs that may provide autocrine or paracrine stimulation. Platelet derived growth factor (PDGF) and its receptors have been localised to cells of ERMs and may play such a role. In this study, comparative data were sought for several other growth factors that have been implicated in ERM formation.
methodsImmunohistochemical staining of ERMs was done for PDGF-A, PDGF-B, basic fibroblast growth factor (bFGF), three isoforms of transforming growth factor beta (TGF-beta), and vascular endothelial growth factor (VEGF) and its receptors, flt-1 and flk-1/KDR. Expression of flt-1 and flk-1/KDR was examined in cultured retinal pigmented epithelial (RPE) cells and retinal glia from postmortem eyes by immunohistochemistry and by reverse transcription coupled to polymerase chain reaction (RT-PCR).
resultsStaining was most intense and most frequently observed for VEGF and PDGF-A, both in vascular and avascular ERMs. The majority of cells stained for VEGF in nine of 11 (81.8%) diabetic ERMs and in 14 of 24 (58.3%) proliferative vitreoretinopathy ERMs. The receptors for VEGF, flt-1, and flk-1/KDR were also identified on cells in ERMs and on cultured RPE cells. By RT-PCR, mRNA for flt-1 was identified in RPE cells and retinal glia, and mRNA for flk-1/KDR was identified in RPE cells.
conclusionsThese data show that VEGF and its receptors are localised to both vascular and avascular ERMs and suggest that VEGF, like PDGF-A, may be an autocrine and paracrine stimulator that may contribute to progression of vascular and avascular ERMs.
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