ArticleAnnals of the rheumatic diseases1997
Enhanced jejunal production of antibodies to Klebsiella and other Enterobacteria in patients with ankylosing spondylitis and rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- The incidence of Proteus mirabilis infection increases in patients on treatment but does not trigger disease activity.Clinical rheumatology · 2006Trial
- Review
- Raised incidence of ankylosing spondylitis among Inuit populations could be due to high HLA-B27 association and starch consumption.Rheumatology international · 2015Review
- The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.Clinical & developmental immunology · 2013Review
- Autoimmunity in Rheumatic Diseases Is Induced by Microbial Infections via Crossreactivity or Molecular Mimicry.Autoimmune diseases · 2012Article
- Ankylosing spondylitis is linked to Klebsiella--the evidence.Clinical rheumatology · 2007Review
- A possible link between Crohn's disease and ankylosing spondylitis via Klebsiella infections.Clinical rheumatology · 2007Review
- Article
- Insights into the Role of Infection in the Spondyloarthropathies.Current rheumatology reports · 2001Review
- The oxidative metabolism of circulating phagocytes in ankylosing spondylitis: determination by whole blood chemiluminescence.Annals of the rheumatic diseases · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo measure gut immunity directly in jejunal fluid in patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA).
methodsAntibodies against three different Enterobacterias were measured in jejunal perfusion fluids (collected by a double balloon perfusion device) of 19 patients with AS, 14 patients with RA, and 22 healthy controls using enzyme linked immunosorbent assay.
resultsThe AS patients had significantly increased jejunal fluid concentrations of IgM, IgG, and IgA class antibodies against Klebsiella pneumoniae, and IgM and IgA class antibodies against Escherichia coli and Proteus mirabilis compared with healthy controls. When compared with the patients with RA, the AS patients had higher concentrations of IgA and IgG class antibodies only against K pneumoniae. The RA patients had higher IgM class antibody concentrations against all three studied Enterobacterias, when compared with the healthy controls, suggesting an enhanced mucosal immune response in these patients. A three month treatment with sulphasalazine did not decrease enterobacterial antibody concentrations in the 10 patients with AS.
conclusionThere is strong direct evidence for an abnormal mucosal humoral immune response particularly to K pneumoniae in patients with AS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.