ArticleInflammation1998
Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis.
Article in Inflammation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.Frontiers in immunology · 2024Review
- Article
- Acute pancreatitis promotes the generation of two different exosome populations.Scientific reports · 2019Article
- Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation.Scientific reports · 2018Article
- Effects of Montelukast in an Experimental Model of Acute Pancreatitis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Article
- Acinar Cell Production of Leukotriene BCellular and molecular gastroenterology and hepatology · 2015Article
- Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.Pancreas · 2011Article
- Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.British journal of pharmacology · 2010Article
- Serum paraoxonase undergoes inhibition and proteolysis during experimental acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
- Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.Gastroenterology · 2006Article
- 5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein.Immunology · 2003Article
- In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats.British journal of pharmacology · 2003Article
- P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine.Thorax · 2002Article
- P-selectin expression and Kupffer cell activation in rat acute pancreatitis.Digestive diseases and sciences · 2000Article
- Effect of peritoneal lavage and lymph ligature on systemic complications of experimental acute pancreatitis.Digestive diseases and sciences · 2000Article
- Role of P-selectin and ICAM-1 in pancreatitis-induced lung inflammation in rats: significance of oxidative stress.Annals of surgery · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of 5-lipoxygenase metabolites of arachidonic acid in the inflammatory response associated with experimental acute pancreatitis has been evaluated. For this purpose, an experimental necrohemorrhagic pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. Neutrophil infiltration was detected in pancreas at 1 and 3 h after the induction of pancreatitis. This was concomitant with increased levels of leukotriene B4 and peptide leukotrienes (C4, D4 and E4). In lung, similar increases in neutrophil infiltration were detected but only 3 h after acute pancreatitis induction, and no changes in leukotriene B4 nor peptide leukotrienes were apparent at this time. These results suggest that after induction of acute pancreatitis, 5-lipoxygenase metabolites could play a role in the inflammatory response in the pancreas, but they are not involved in the inflammatory response in lung.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.