ArticleProceedings of the National Academy of Sciences of the United States of America1998
Genomic sequences of aldolase C (Zebrin II) direct lacZ expression exclusively in non-neuronal cells of transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury.Neuroscience bulletin · 2025Review
- Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration.Aging and disease · 2024Article
- Screening differentially expressed proteins of coronary heart disease with congenital cold syndrome based on tandem mass tag (TMT) technology.Bioengineered · 2021Article
- Midbrain Dopaminergic Neuron Development at the Single Cell Level:Frontiers in cell and developmental biology · 2020Review
- Astrocytogenesis: where, when, and how.F1000Research · 2020Review
- Physiology of Astroglia.Physiological reviews · 2018Review
- Stratification of astrocytes in healthy and diseased brain.Brain pathology (Zurich, Switzerland) · 2017Article
- Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis.Journal of lasers in medical sciences · 2017Article
- Compartmentation of the cerebellar cortex: adaptation to lifestyle in the star-nosed mole Condylura cristata.Cerebellum (London, England) · 2015Article
- Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord.Development (Cambridge, England) · 2014Article
- Article
- Purkinje cell compartmentalization in the cerebellum of the spontaneous mutant mouse dreher.Brain structure & function · 2014Article
- Article
- Compartmentation of the cerebellar cortex in the naked mole-rat (Heterocephalus glaber).Cerebellum (London, England) · 2011Article
- On the architecture of the posterior zone of the cerebellum.Cerebellum (London, England) · 2011Article
- Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration.Neurobiology of disease · 2011Article
- Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation.PloS one · 2008Article
- Fructose metabolism in the cerebellum.Cerebellum (London, England) · 2007Review
- Aldolases a and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
9 authors.
Funding
Abstract
Aldolase C is regarded as the brain-specific form of fructose-1, 6-bisphosphate aldolase whereas aldolase A is regarded as muscle-specific. In situ hybridization of mouse central nervous system using isozyme-specific probes revealed that aldolase A and C are expressed in complementary cell types. With the exception of cerebellar Purkinje cells, aldolase A mRNA is found in neurons; aldolase C message is detected in astrocytes, some cells of the pia mater, and Purkinje cells. We isolated aldolase C genomic clones that span the entire protein coding region from 1.5 kb 5' to the transcription start site to 0.5 kb 3' to the end of the last exon. The bacterial gene, lacZ, was inserted in two different locations and the constructs tested in transgenic mice. When the protein coding sequences were replaced with lacZ, three of five transgenic lines expressed beta-galactosidase only in cells of the pia mater; one line also expressed in astrocyte-like cells. When lacZ was inserted into the final exon (and all structural gene sequences were retained) transgene expression was observed in astrocytes in all regions of the central nervous system as well as in pial cells. Thus, with the exception of Purkinje cell expression, the behavior of the full-length transgene mimics the endogenous aldolase C gene. The results with the shorter transgene suggest that additional enhancer elements exist within the intragenic sequences. The absence of Purkinje cell staining suggests that the cis elements required for this expression must be located outside of the sequences used in this study.
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