ArticleProceedings of the National Academy of Sciences of the United States of America1998
Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Multiple solutions at the genomic level in response to selective breeding for high locomotor activity.Genetics · 2023Article
- NCAM140 and pCREB Expression after Tianeptine Treatment of SH-SY5Y Cells.Psychiatry investigation · 2014Article
- Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.Endocrinology · 2009Article
- Cell adhesion molecules: signalling functions at the synapse.Nature reviews. Neuroscience · 2007Review
- SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects.Human genetics · 2005Article
- Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Impaired motor coordination in mice that lack punc.Molecular and cellular biology · 2001Article
- A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Revisiting the function of PSA-NCAM in the nervous system.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translation initiation sites of the N-CAM gene. This insertion disrupts the gene and places the expression of beta-galactosidase under the control of the N-CAM promoter. Animals homozygous for the disrupted allele did not express N-CAM mRNA or protein, but the pattern of beta-galactosidase expression in heterozygous and homozygous embryos was similar to that of N-CAM mRNA in wild-type animals. The homozygotes exhibited many of the morphological abnormalities observed in previously reported N-CAM knockout mice, with the exception that hippocampal long-term potentiation in the Schaffer collaterals was identical in homozygous, heterozygous, and wild-type animals. Heterozygous mice were used to examine the regulation of the N-CAM promoter in response to enhanced synaptic transmission. Treatment of the mice with an ampakine, an allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that enhances normal glutamate-mediated synaptic transmission, increased the expression of beta-galactosidase in vivo as well as in tissue slices in vitro. Similar treatments also increased the expression of N-CAM mRNA in the heterozygotes. The effects of ampakine in slices were strongly reduced in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an AMPA receptor antagonist. Taken together, these results indicate that facilitation of AMPA receptor-mediated transmission leads to activation of the N-CAM promoter and provide support for the hypothesis that N-CAM synthesis is regulated in part by synaptic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.