ArticleProceedings of the National Academy of Sciences of the United States of America1998
The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression.iScience · 2023Article
- Gene structure, SNP screening and growth correlation analysis of the preproinsulin gene in grass carp (Journal of genetics · 2021Article
- Correlation analysis of mandarin fish (Journal of genetics · 2019Article
- Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display.Antibodies (Basel, Switzerland) · 2018Article
- Genetic diversity of MYH3 gene associated with growth and carcass traits in Chinese Qinchuan cattle.Molecular biology reports · 2013Article
- AID and Apobec3G haphazard deamination and mutational diversity.Cellular and molecular life sciences : CMLS · 2013Review
- Molecular analysis of the first intron in the bovine myostatin gene.Molecular biology reports · 2011Article
- The zebrafish IgH locus contains multiple transcriptional regulatory regions.Developmental and comparative immunology · 2011Article
- Molecular cloning, tissue expression and association of porcine NR4A1 gene with reproductive traits.Molecular biology reports · 2011Article
- Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.The Journal of experimental medicine · 2006Article
- AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2006Review
- Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.Molecular immunology · 2006Article
- Antibody diversification: mutational mechanisms and oncogenesis.Immunologic research · 2006Review
- Evolution of transcriptional enhancers in the immunoglobulin heavy-chain gene: functional characteristics of the zebrafish Emu3' enhancer.Immunogenetics · 2005Article
- Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation.Immunology · 2003Article
- The reverse transcriptase model of somatic hypermutation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Chromosome breakage in the Prader-Willi and Angelman syndromes involves recombination between large, transcribed repeats at proximal and distal breakpoints.American journal of human genetics · 1999Article
- An experimental solution for the Luria-Delbrück fluctuation problem in measuring hypermutation rates.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Hypermutation at the Ig loci is confined to the area between the promoter and the intronic enhancer, which includes the rearranged variable region gene segment. We identified factors that contribute to the site-specificity at the heavy chain locus. We found that distance from both the promoter and the intronic enhancer is crucial in hypermutation. The presence of the enhancer is required, and, in contrast to its definition for transcriptional activity, its effect is orientation-sensitive.
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