ArticleProceedings of the National Academy of Sciences of the United States of America1998
Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 112 citations in OpenAlex.
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- Gene(s) and individual feeding behavior: Exploring eco-evolutionary dynamics underlying left-right asymmetry in the scale-eating cichlid fishEcology and evolution · 2018Article
- Gain of cis-regulatory activities underlies novel domains of wingless gene expression in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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- The role of self-organization in developmental evolution.Theory in biosciences = Theorie in den Biowissenschaften · 2014Article
- Evolution of transcriptional enhancers and animal diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
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- cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Molecular and cellular biology · 2010Article
- Comparison of diverse developmental transcriptomes reveals that coexpression of gene neighbors is not evolutionarily conserved.Genome research · 2009Article
- Homology of dipteran bristles and lepidopteran scales: requirement for the Bombyx mori achaete-scute homologue ASH2.Genetics · 2009Article
- Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Vertebrate conserved non coding DNA regions have a high persistence length and a short persistence time.BMC genomics · 2007Article
- Emerging principles of regulatory evolution.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Differential Hox gene expression between vertebrate species has been implicated in the divergence of axial morphology. To examine this relationship, we have compared expression and transcriptional regulation of Hoxc8 in chicken and mouse. In both species, expression of Hoxc8 in the paraxial mesoderm and neural tube is associated with midthoracic and brachial identities, respectively. During embryogenesis, there is a temporal delay in the activation of Hoxc8 in chicken compared with mouse. As a result, chicken Hoxc8 expression in the paraxial mesoderm is at a posterior axial level, extending over a smaller domain compared with mouse Hoxc8 expression. This finding is consistent with a shorter thoracic region in chicken compared with mouse. In addition, the chicken Hoxc8 early enhancer, differing from its mouse counterpart in only a few specific nucleotides, directs a reporter gene expression to a more posterior domain in transgenic mouse embryos. These findings are consistent with the concept that the diversification of axial morphology has been achieved through changes in cis-regulation of developmental control genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.