ArticleProceedings of the National Academy of Sciences of the United States of America1998
Presence and phosphorylation of transcription factors in developing dendrites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 150 citations in OpenAlex.
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- cAMP response element-binding protein and Yes-associated protein form a feedback loop that promotes neurite outgrowth.Journal of cellular and molecular medicine · 2018Article
- Local translation in neuronal compartments: how local is local?EMBO reports · 2017Review
- Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cells.Molecular psychiatry · 2016Article
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- The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience.Nature communications · 2014Article
- Axonal transcription factors: novel regulators of growth cone-to-nucleus signaling.Developmental neurobiology · 2014Review
- Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila.Journal of cell science · 2013Article
- Dendritic protein synthesis in the normal and diseased brain.Neuroscience · 2013Review
- Quantitative biology of single neurons.Journal of the Royal Society, Interface · 2012Review
- Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Multiple transcription factor families regulate axon growth and regeneration.Developmental neurobiology · 2011Review
- Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons.Brain research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In screening amplified poly(A) mRNA from hippocampal dendrites and growth cones in culture to determine candidates for local translation, we found that select transcription factor mRNAs were present. We hypothesized that synthesis of transcription factor proteins within dendrites would provide a direct signaling pathway between the distal dendrite and the nucleus resulting in modulation of gene expression important for neuronal differentiation. To evaluate this possibility, radiolabeled amplified antisense RNA was used to probe slot blots of transcription factor cDNAs as well as arrayed blots of zinc finger transcription factors. The mRNAs encoding the cAMP response element binding protein (CREB), zif 268, and one putative transcription factor were detected. We expanded upon these results showing that CREB protein is present in dendrites, that translation of CREB mRNA in isolated dendrites is feasible and that CREB protein found in dendrites can interact with the cis-acting cyclic AMP reponse element DNA sequence by using an in situ Southwestern assay. Further, CREB protein in dendrites is not transported to this site from the cell body because fluorescently tagged CREB microperfused into the soma did not diffuse into the dendrites. In addition, CREB protein microperfused into dendrites was rapidly transported to the nucleus, its likely site of bioactivity. Lastly, by using the isolated dendrite system we show that phosphorylation of Ser-133 on CREB protein can occur in isolated dendrites independent of the nucleus. These data provide a regulatory pathway in which transcription factors synthesized and posttranslationally modified in dendrites directly alter gene expression bypassing the integration of signal transduction pathways that converge on the nucleus.
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