ArticleProceedings of the National Academy of Sciences of the United States of America1998
A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 76 citations in OpenAlex.
- Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.Frontiers in immunology · 2023Article
- The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitisTurkish journal of medical sciences · 2021Article
- Mechanism of membrane fusion: protein-protein interaction and beyond.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.Cancer science · 2018Article
- A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma.Oncology letters · 2017Article
- Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein.Journal of neurovirology · 2016Article
- MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder.Molecular medicine reports · 2016Article
- Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders.Brain sciences · 2016Review
- Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.Proteomics · 2016Article
- Overexpression of TIP30 inhibits the growth and invasion of glioma cells.Molecular medicine reports · 2016Article
- NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter.Retrovirology · 2014Article
- Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.Cell death & disease · 2014Article
- TIP30: A Novel Tumor-Suppressor Gene.Oncology research · 2014Review
- High serum HTATIP2/TIP30 level in serous ovarian cancer as prognostic or diagnostic marker.European journal of medical research · 2013Article
- TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice.Oncogene · 2013Article
- TIP30 directly binds p53 tumor suppressor protein in vitro.Molecules and cells · 2012Article
- A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.The Journal of biological chemistry · 2011Article
- Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors.Cancer research · 2010Article
- Expression of TIP30 tumor suppressor gene is down-regulated in human colorectal carcinoma.Digestive diseases and sciences · 2010Article
- Decreased TIP30 expression promotes tumor metastasis in lung cancer.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Replication of HIV-1 requires the viral Tat protein, which increases the extent of transcription elongation by RNA polymerase II after activation at the single viral long terminal repeat (LTR) promoter. This effect of Tat on transcription requires Tat interactions with a 5' region (TAR) in nascent transcripts as well as Tat-specific cofactors. The present study identifies a cellular protein, TIP30, that interacts with Tat and with an SRB-containing RNA polymerase II complex both in vivo and in vitro. Coexpression of TIP30 specifically enhances transactivation by Tat in transfected cells, and immunodepletion of TIP30 from nuclear extracts abolishes Tat-activated transcription without affecting Tat-independent transcription. These results implicate TIP30 as a specific coactivator that may enhance formation of a Tat-RNA polymerase II holoenzyme complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.