ArticleProceedings of the National Academy of Sciences of the United States of America1998
Domain requirements for the Dock adapter protein in growth- cone signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
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- Precise levels of the Drosophila adaptor protein Dreadlocks maintain the size and stability of germline ring canals.Journal of cell science · 2021Article
- Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.Frontiers in cell and developmental biology · 2021Review
- Alternatively spliced down syndrome cell adhesion molecule (Dscam) controls innate immunity in crab.The Journal of biological chemistry · 2019Article
- Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.Molecular cell · 2018Article
- Vamana Couples Fat Signaling to the Hippo Pathway.Developmental cell · 2016Article
- Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.Cell communication and signaling : CCS · 2014Article
- A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility.The Journal of biological chemistry · 2014Article
- Independent signaling by Drosophila insulin receptor for axon guidance and growth.Frontiers in physiology · 2013Article
- Stoichiometry of Nck-dependent actin polymerization in living cells.The Journal of cell biology · 2012Article
- Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A convergently regulate the synaptic ratio of ionotropic glutamate receptor subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Genes & development · 2007Article
- EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function.Molecular biology of the cell · 2007Article
- Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Review
- Dissecting Nck/Dock signaling pathways in Drosophila visual system.International journal of biological sciences · 2005Review
- Article
- Soluble guanylate cyclase is required during development for visual system function in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrosine phosphorylation has been implicated in growth-cone guidance through genetic, biochemical, and pharmacological studies. Adapter proteins containing src homology 2 (SH2) domains and src homology 3 (SH3) domains provide a means of linking guidance signaling through phosphotyrosine to downstream effectors regulating growth-cone motility. The Drosophila adapter, Dreadlocks (Dock), the homolog of mammalian Nck containing three N-terminal SH3 domains and a single SH2 domain, is highly specialized for growth-cone guidance. In this paper, we demonstrate that Dock can couple signals in either an SH2-dependent or an SH2-independent fashion in photoreceptor (R cell) growth cones, and that Dock displays different domain requirements in different neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.