ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay.PLoS biology · 2025Article
- Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity.PLoS genetics · 2023Article
- Acute Regulation of Habituation Learning via Posttranslational Palmitoylation.Current biology : CB · 2020Article
- Electrophysiological analysis of synaptic transmission in Drosophila.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning.Neuron · 2015Article
- Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, and impaired adult social behavior and activity patterns.Journal of neurogenetics · 2015Article
- The transcription factors islet and Lim3 combinatorially regulate ion channel gene expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Habituation of reflexive and motivated behavior in mice with deficient BK channel function.Frontiers in integrative neuroscience · 2013Article
- A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.PLoS genetics · 2013Article
- Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress.PLoS genetics · 2013Article
- Constitutive activation of Ca2+/calmodulin-dependent protein kinase II during development impairs central cholinergic transmission in a circuit underlying escape behavior in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.PloS one · 2011Article
- SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila.PloS one · 2011Article
- Microarray-based transcriptomic analysis of differences between long-term gregarious and solitarious desert locusts.PloS one · 2011Article
- Electrophysiological recordings from the Drosophila giant fiber system (GFS).Cold Spring Harbor protocols · 2010Article
- Neurogenetic approaches to habituation and dishabituation in Drosophila.Neurobiology of learning and memory · 2009Review
- The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Potassium channels have been implicated in central roles in activity-dependent neural plasticity. The giant fiber escape pathway of Drosophila has been established as a model for analyzing habituation and its modification by memory mutations in an identified circuit. Several genes in Drosophila encoding K+ channel subunits have been characterized, permitting examination of the contributions of specific channel subunits to simple conditioning in an identified circuit that is amenable to genetic analysis. Our results show that mutations altering each of four K+ channel subunits (Sh, slo, eag, and Hk) have distinct effects on habituation at least as strong as those of dunce and rutabaga, memory mutants with defective cAMP metabolism (). Habituation, spontaneous recovery, and dishabituation of the electrically stimulated long-latency giant fiber pathway response were shown in each mutant type. Mutations of Sh (voltage-gated) and slo (Ca2+-gated) subunits enhanced and slowed habituation, respectively. However, mutations of eag and Hk subunits, which confer K+-current modulation, had even more extreme phenotypes, again enhancing and slowing habituation, respectively. In double mutants, Sh mutations moderated the strong phenotypes of eag and Hk, suggesting that their modulatory functions are best expressed in the presence of intact Sh subunits. Nonactivity-dependent responses (refractory period and latency) at two stages of the circuit were altered only in some mutants and do not account for modifications of habituation. Furthermore, failures of the long-latency response during habituation, which normally occur in labile connections in the brain, could be induced in the thoracic circuit stage in Hk mutants. Our work indicates that different K+ channel subunits play distinct roles in activity-dependent neural plasticity and thus can be incorporated along with second messenger "memory" loci to enrich the genetic analysis of learning and memory.
Indexed as
Identifiers
9482810PMC6792913W2127263164What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.