ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Neuromodulatory inputs maintain expression of a lobster motor pattern-generating network in a modulation-dependent state: evidence from long-term decentralization in vitro.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 107 citations in OpenAlex.
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- Removal of endogenous neuromodulators in a small motor network enhances responsiveness to neuromodulation.Journal of neurophysiology · 2017Article
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- Homeostatic plasticity of excitability in crustacean central pattern generator networks.Current opinion in neurobiology · 2017Review
- Consequences of acute and long-term removal of neuromodulatory input on the episodic gastric rhythm of the crab Cancer borealis.Journal of neurophysiology · 2015Article
- Degradation of extracellular chondroitin sulfate delays recovery of network activity after perturbation.Journal of neurophysiology · 2015Article
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- Dopaminergic tone persistently regulates voltage-gated ion current densities through the D1R-PKA axis, RNA polymerase II transcription, RNAi, mTORC1, and translation.Frontiers in cellular neuroscience · 2014Article
- Ionic current correlations underlie the global tuning of large numbers of neuronal activity attributes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromodulatory inputs play a critical role in governing the expression of rhythmic motor output by the pyloric network in the crustacean stomatogastric ganglion (STG). When these inputs are removed by cutting the primarily afferent stomatogastric nerve (stn) to the STG, pyloric neurons rapidly lose their ability to burst spontaneously, and the network falls silent. By using extracellular motor nerve recordings from long-term organotypic preparations of the stomatogastric nervous system of the lobster Jasus lalandii, we are investigating whether modulatory inputs exert long-term regulatory influences on the pyloric network operation in addition to relatively short-term neuromodulation. When decentralized (stn cut), quiescent STGs are maintained in organ culture, pyloric rhythmicity gradually returns within 3-5 d and is similar to, albeit slower than, the triphasic motor pattern expressed when the stn is intact. This recovery of network activity still occurred after photoinactivation of axotomized input terminals in the isolated STG after migration of Lucifer yellow. The recovery does not depend on action potential generation, because it also occurred in STGs maintained in TTX-containing saline after decentralization. Resumption of rhythmicity was also not activity-dependent, because recovery still occurred in STGs that were chronically depolarized with elevated K+ saline or were maintained continuously active with the muscarinic agonist oxotremorine after decentralization. We conclude that the prolonged absence of extraganglionic modulatory inputs to the pyloric network allows expression of an inherent rhythmogenic capability that is normally maintained in a strictly conditional state when these extrinsic influences are present.
Indexed as
Identifiers
9482805PMC6792931W1597922533What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.