ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Metabotropic glutamate receptors negatively regulate melatonin synthesis in rat pinealocytes.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 83 citations in OpenAlex.
- Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers.Current research in toxicology · 2025Article
- Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats.Antioxidants (Basel, Switzerland) · 2023Article
- Methylmercury plus Ethanol Exposure: How Much Does This Combination Affect Emotionality?International journal of molecular sciences · 2021Review
- Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Negative regulation of melatonin secretion by melatonin receptors in ovine pinealocytes.PloS one · 2021Article
- Neuromodulation of the Pineal Gland via Electrical Stimulation of Its Sympathetic Innervation Pathway.Frontiers in neuroscience · 2020Review
- TMEM16A and TMEM16B channel proteins generate CaThe Journal of biological chemistry · 2018Article
- Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum.Surgical neurology international · 2018Review
- Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.International journal of molecular sciences · 2017Review
- Modulation of Ca2+ oscillation and melatonin secretion by BKCa channel activity in rat pinealocytes.American journal of physiology. Cell physiology · 2016Article
- High membrane permeability for melatonin.The Journal of general physiology · 2016Article
- The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling.Cell death and differentiation · 2015Article
- Modulation of nicotinic receptor channels by adrenergic stimulation in rat pinealocytes.American journal of physiology. Cell physiology · 2014Article
- Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation.BioMed research international · 2013Article
- Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Analysis of daily and circadian gene expression in the rat pineal gland.Neuroscience research · 2008Article
- Secretion of L-glutamate from osteoclasts through transcytosis.The EMBO journal · 2006Article
- Acetylcholine triggers L-glutamate exocytosis via nicotinic receptors and inhibits melatonin synthesis in rat pinealocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rat pinealocytes receive noradrenergic innervation that stimulates melatonin synthesis in a cAMP-mediated manner. In addition to melatonin, we showed previously that pinealocytes secrete L-glutamate through an exocytic mechanism. The released glutamate inhibits norepinephrine (NE)-dependent melatonin synthesis. Consistent with this observation, specific agonists of class II metabotropic glutamate receptors (mGluRs), including 1-(1S,3R)-aminocyclopentane-1,3-dicarboxylic acid (tACPD), inhibited NE-dependent melatonin synthesis, whereas agonists for other types of glutamate receptors did not. Furthermore, reverse transcription-PCR, Northern blotting, and immunohistochemistry analyses indicated expression of class II mGluR3 in pinealocytes. Inhibitory guanine nucleotide-binding protein (Gi) was also detected in pinealocytes. L-Glutamate or agonists of class II receptors decreased NE- or forskolin-dependent increase of cAMP and serotonin-N-acetyltransferase activities to similar extents. These effects were blocked by pertussis toxin or dibutyryl cAMP. These results indicate that the inhibitory cAMP cascade is involved in the glutamate-evoked inhibition of melatonin synthesis. We propose that the glutaminergic system negatively regulates NE-dependent melatonin synthesis in rat pinealocytes.
Indexed as
Identifiers
9482792PMC6792920W1931173751What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.