ArticleThe EMBO journal1998
Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 114 citations in OpenAlex.
- Review
- Bifunctional cross-linking approaches for mass spectrometry-based investigation of nucleic acids and protein-nucleic acid assemblies.Methods (San Diego, Calif.) · 2018Article
- Essential is not irreplaceable: fitness dynamics of experimental E. coli RNase P RNA heterologous replacement.Journal of molecular evolution · 2014Article
- Solution structure of RNase P RNA.RNA (New York, N.Y.) · 2011Article
- Predicting and modeling RNA architecture.Cold Spring Harbor perspectives in biology · 2011Review
- Of proteins and RNA: the RNase P/MRP family.RNA (New York, N.Y.) · 2010Review
- RNA crosslinking methods.Methods in enzymology · 2009Article
- Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.RNA (New York, N.Y.) · 2007Article
- Structure and function of eukaryotic Ribonuclease P RNA.Molecular cell · 2006Article
- Frequency of RNA-RNA interaction in a model of the RNA World.RNA (New York, N.Y.) · 2006Article
- Protein activation of a ribozyme: the role of bacterial RNase P protein.The EMBO journal · 2005Article
- Crystal structure of a bacterial ribonuclease P RNA.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing.RNA (New York, N.Y.) · 2005Article
- Structural implications of novel diversity in eucaryal RNase P RNA.RNA (New York, N.Y.) · 2005Article
- Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes.Nucleic acids research · 2005Article
- Interactions between RNase P protein subunits in archaea.Archaea (Vancouver, B.C.) · 2004Article
- Interaction of the Bacillus subtilis RNase P with the 30S ribosomal subunit.RNA (New York, N.Y.) · 2004Article
- Change of RNase P RNA function by single base mutation correlates with perturbation of metal ion binding in P4 as determined by NMR spectroscopy.Nucleic acids research · 2004Article
- Structure and functional properties of prokaryotic small noncoding RNAs.Folia microbiologica · 2003Review
- Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.RNA (New York, N.Y.) · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial ribonuclease P contains a catalytic RNA subunit that cleaves precursor sequences from the 5' ends of pre-tRNAs. The RNase P RNAs from Bacillus subtilis and Escherichia coli each contain several unique secondary structural elements not present in the other. To understand better how these phylogenetically variable elements affect the global architecture of the ribozyme, photoaffinity cross-linking studies were carried out. Photolysis of photoagents attached at homologous sites in the two RNAs results in nearly identical cross-linking patterns, consistent with the homology of the RNAs and indicating that these RNAs contain a common, core tertiary structure. Distance constraints were used to derive tertiary structure models using a molecular mechanics-based modeling protocol. The resulting superimposition of large sets of equivalent models provides a low resolution (5-10 A) structure for each RNA. Comparison of these structure models shows that the conserved core helices occupy similar positions in space. Variably present helical elements that may play a role in global structural stability are found at the periphery of the core structure. The P5.1 and P15.1 helical elements, unique to the B.subtilis RNase P RNA, and the P6/16/17 helices, unique to the E.coli RNA, occupy similar positions in the structure models and, therefore, may have analogous structural function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.