ArticleThe EMBO journal1998
Mutations in RNAs of both ribosomal subunits cause defects in translation termination.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- A cascade of structural rearrangements positions peptide release factor 2 for polypeptide hydrolysis on the ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Epitranscriptomics in parasitic protists: Role of RNA chemical modifications in posttranscriptional gene regulation.PLoS pathogens · 2022Review
- Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain.Journal of molecular biology · 2020Article
- Distinct functional classes of ram mutations in 16S rRNA.RNA (New York, N.Y.) · 2014Article
- Missense suppressor mutations in 16S rRNA reveal the importance of helices h8 and h14 in aminoacyl-tRNA selection.RNA (New York, N.Y.) · 2010Article
- A peptide chain release factor 2 affects the stability of UGA-containing transcripts in Arabidopsis chloroplasts.The Plant cell · 2002Article
- Mutational eidence for a functional connection between two domains of 23S rRNA in translation termination.Journal of bacteriology · 2002Article
- Highly conserved NIKS tetrapeptide is functionally essential in eukaryotic translation termination factor eRF1.RNA (New York, N.Y.) · 2002Article
- Mutations in the GTPase center of Escherichia coli 23S rRNA indicate release factor 2-interactive sites.Journal of bacteriology · 2002Article
- The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246.RNA (New York, N.Y.) · 2000Article
- Suppression of eukaryotic translation termination by selected RNAs.RNA (New York, N.Y.) · 2000Article
- Mutations in helix 27 of the yeast Saccharomyces cerevisiae 18S rRNA affect the function of the decoding center of the ribosome.RNA (New York, N.Y.) · 2000Article
- Expression of UGA-containing Mycoplasma genes in Bacillus subtilis.Journal of bacteriology · 2000Article
- Translational suppressors and antisuppressors alter the efficiency of the Ty1 programmed translational frameshift.RNA (New York, N.Y.) · 1999Article
- Suppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.Journal of bacteriology · 1999Article
- Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.RNA (New York, N.Y.) · 1999Article
- Posttranscriptional control of gene expression in yeast.Microbiology and molecular biology reviews : MMBR · 1998Review
- Analysis of the conformation of the 3' major domain of Escherichia coli16S ribosomal RNA using site-directed photoaffinity crosslinking.RNA (New York, N.Y.) · 1998Article
- An rRNA fragment and its antisense can alter decoding of genetic information.Journal of bacteriology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in RNAs of both subunits of the Escherichia coli ribosome caused defects in catalysis of peptidyl-tRNA hydrolysis in a realistic in vitro termination system. Assaying the two codon-dependent cytoplasmic proteins that drive termination, RF1 and RF2, we observed large defects with RF2 but not with RF1, a result consistent with the in vivo properties of the mutants. Our study presents the first direct in vitro evidence demonstrating the involvement of RNAs from both the large and the small ribosomal subunits in catalysis of peptidyl-tRNA hydrolysis during termination of protein biosynthesis. The results and conclusions are of general significance since the rRNA nucleotides studied have been virtually universally conserved throughout evolution. Our findings suggest a novel role for rRNAs of both subunits as molecular transmitters of a signal for termination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.