ArticleThe EMBO journal1998
Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 145 citations in OpenAlex.
- Article
- Maintaining Transcriptional Specificity Through Mitosis.Annual review of genomics and human genetics · 2022Review
- Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription.Nucleic acids research · 2022Article
- Glucocorticoid receptor signalling activates YAP in breast cancer.Nature communications · 2017Article
- Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation.Epigenetics & chromatin · 2017Article
- Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP-dependent chromatin remodeling factors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Linker histone H1 and protein-protein interactions.Biochimica et biophysica acta · 2016Review
- Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor.Molecular and cellular endocrinology · 2013Review
- H1 histones: current perspectives and challenges.Nucleic acids research · 2013Review
- Binding of NF-κB to nucleosomes: effect of translational positioning, nucleosome remodeling and linker histone H1.PLoS genetics · 2013Article
- Histone phosphorylation: a chromatin modification involved in diverse nuclear events.Epigenetics · 2012Review
- Chromatin remodeling during glucocorticoid receptor regulated transactivation.Biochimica et biophysica acta · 2012Review
- Profiling of linker histone variants in ovarian cancer.Frontiers in bioscience (Landmark edition) · 2012Review
- Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome.The Journal of biological chemistry · 2011Article
- Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.Genes & development · 2011Article
- Differential glucocorticoid receptor-mediated transcription mechanisms.The Journal of biological chemistry · 2011Article
- P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.The Journal of biological chemistry · 2010Article
- Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II.The Journal of cell biology · 2010Article
- Erk signaling and chromatin remodeling in MMTV promoter activation by progestins.Nuclear receptor signaling · 2009Review
- Kinetic complexity of the global response to glucocorticoid receptor action.Endocrinology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids rapidly induce transcription from the mouse mammary tumour virus (MMTV) promoter via a glucocorticoid receptor (GR)-mediated chromatin disruption event. This remodelling of chromatin is transient such that upon prolonged exposure to hormone the promoter becomes refractory to glucocorticoids. We demonstrate that this refractory state requires the continual presence of hormone and can be reversed by its removal. Our experiments show that the promoter is inactivated via a mechanism whereby histone H1 is dephosphorylated in response to glucocorticoids. Removal of glucocorticoids results in the rephosphorylation of histone H1 and the reacquisition of transcriptional competence by the promoter. This response is specific for the MMTV promoter assembled as chromatin and is not observed for another inducible gene or transiently transfected MMTV DNA. Finally, we demonstrate that H1 on the MMTV promoter is dephosphorylated when the promoter is unresponsive to glucocorticoids. These studies indicate that phosphorylated H1 is intimately linked with the GR-mediated disruption of MMTV chromatin in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.