ArticleThe EMBO journal1998
A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- UCS Chaperone Folding of the Myosin Head: A Function That Evolved before Animals and Fungi Diverged from a Common Ancestor More than a Billion Years Ago.Biomolecules · 2022Review
- A RID-like putative cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina.PLoS genetics · 2019Article
- Myosin chaperones.Current opinion in structural biology · 2014Review
- The UNC-45 myosin chaperone: from worms to flies to vertebrates.International review of cell and molecular biology · 2014Review
- Systematic deletion of homeobox genes in Podospora anserina uncovers their roles in shaping the fruiting body.PloS one · 2012Article
- X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster.Structure (London, England : 1993) · 2011Article
- Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.PloS one · 2008Article
- Unc45 activates Hsp90-dependent folding of the myosin motor domain.The Journal of biological chemistry · 2008Article
- Gene deletion and allelic replacement in the filamentous fungus Podospora anserina.Current genetics · 2008Article
- UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.The Journal of cell biology · 2004Article
- Article
- RNA asymmetric distribution and daughter/mother differentiation in yeast.Current opinion in microbiology · 2003Review
- She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae.Molecular biology of the cell · 2003Article
- Green fluorescent protein is lighting up fungal biology.Applied and environmental microbiology · 2001Review
- Article
- Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain A.The Journal of cell biology · 2000Article
- Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Podospora anserina cro1 gene was identified as a gene required for sexual sporulation. Crosses homozygous for the cro1-1 mutation yield fruiting bodies which produce few asci due to the formation of giant plurinucleate cells instead of dikaryotic cells after fertilization. This defect does not impair karyogamy, but meioses of the resultant polyploid nuclei are most often abortive. Cytological studies suggest that the primary defect of the mutant is its inability to form septa between the daughter nuclei after each mitosis, a step specific for normal dikaryotic cell divisions. The cro1-1 mutant would thus be unable to leave the syncytial vegetative state while abiding by the meiotic programme. cro1-1 also shows defects in ascospore germination and growth rate. GFP-tagging of the CRO1 protein reveals that it is a cytosolic protein mainly expressed at the beginning of the dikaryotic stage and at the time of ascospore maturation. The CRO1 protein exhibits significant similarity to the SHE4 protein, which is required for asymmetric mating-type switching in budding yeast cells. Thus, a gene involved in asymmetric cell divisions in a unicellular organism plays a key role at the transition between the syncytial (vegetative) state and the cellular (sexual) state in a filamentous fungus.
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