Evidence map›Paper›PMID 9480863›Full record

ArticleThe Biochemical journal1998

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes.

D Thomas, H Y Kim, R Morgan, M R Hanley

Open access · bronzeAbstract read
In one paragraph

Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

D ThomasDepartment of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, USA.
H Y Kim
R Morgan
M R Hanley
University of California, Davis · US

Funding

TRAINING IN CARDIOVASCULAR AND NEUROPHYSIOLOGYT32HL007682 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI LONGHURST, JOHN C · 1992 to 1996
–
NHLBI NIH HHS T32HL07682
6 · The paper itself

Abstract

Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

Indexed as

AnimalsBiological FactorsCalciumCalcium ChannelsCalcium-Transporting ATPaseseIF-2 KinaseElectrophysiologyMicroinjectionsOocytesXenopusBiological FactorsCalciumCalcium ChannelsCalcium-Transporting ATPaseseIF-2 Kinase

Identifiers

PMID9480863
PMCPMC1219178
OpenAlexW2406111669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.