Evidence map›Paper›PMID 9479577›Full record

ReviewImmunologic research1998

Antigen receptor-initiated signals for B cell development and selection.

J G Monroe

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

J G MonroeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA. monroej@mail.med.upenn.edu
Philadelphia University · US

Funding

REGULATED B-CELL UNRESPONSIVENESS AND TOLERANCER01AI032592 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHOI, YONGWON · 1993 to 2011
$3.9M
STUDIES OF RECEPTOR IMMUNOGLOBULIN MEDIATED SIGNALLINGR01AI023568 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MONROE, JOHN G · 1990 to 2000
$271k
STUDIES OF RECEPTOR IMMUNOGLOBULIN MEDIATED SIGNALLINGR23AI023568 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MONROE, JOHN G · 1985 to 1987
–
NIAID NIH HHS AI23568NIAID NIH HHS AI32592
6 · The paper itself

Abstract

The B cell antigen receptor or signaling components of this receptor play varying roles in determining the fate of the B cell at different stages of B cell development. Signals generated through this receptor complex or its various components determine the survival, progression, expansion, and activation of the B cell. Factors that determine the fate of the B cell following antigen receptor engagement include the developmental stage, coreceptor expression, degree and stability of ligand-receptor engagement, and the availability of T cell-derived secondary signals. The author's laboratory is interested in defining the molecular processes linking B cell antigen receptor signaling to these specific cellular responses in the context of antigen-independent and dependent B cell development. Here our current progress and thinking with regard to the determination between negative selection and activation as it pertains to the transition from the immature- to the mature-stage B cell will be discussed.

Indexed as

AnimalsB-LymphocytesCell DifferentiationHumansLigandsLymphocyte CooperationReceptors, Antigen, B-CellSignal TransductionT-LymphocytesLigandsReceptors, Antigen, B-Cell

Identifiers

PMID9479577
OpenAlexW2011514784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.