ArticleGenetics1998
Genetic mapping of quantitative trait loci affecting susceptibility to Marek's disease virus induced tumors in F2 intercross chickens.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 191 citations in OpenAlex.
- Integrated transcriptomic and metabolomic analysis identifies host response mechanisms to oncogenic Marek's disease virus in Wenchang chickens.Veterinary research · 2025Article
- scRNA seq of an F1 cross of Marek's disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators.Scientific reports · 2025Article
- Mapping quantitative trait loci regions associated with Marek's disease on chicken autosomes by means of selective DNA pooling.Scientific reports · 2024Article
- Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways.Veterinary sciences · 2024Article
- A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Contribution of the TCRβ Repertoire to Marek's Disease Genetic Resistance in the Chicken.Viruses · 2023Article
- Selection for Favorable Health Traits: A Potential Approach to Cope with Diseases in Farm Animals.Animals : an open access journal from MDPI · 2020Review
- Article
- Seed protein content and its relationships with agronomic traits in pigeonpea is controlled by both main and epistatic effects QTLs.Scientific reports · 2020Article
- Genetic differences in host infectivity affect disease spread and survival in epidemics.Scientific reports · 2019Article
- Article
- Genome-wide association analysis of intra-specific QTL associated with the resistance for enteric septicemia of catfish.Molecular genetics and genomics : MGG · 2018Article
- Characterization of Copy Number Variation's Potential Role in Marek's Disease.International journal of molecular sciences · 2017Article
- Article
- Virus and host genomic, molecular, and cellular interactions during Marek's disease pathogenesis and oncogenesis.Poultry science · 2016Review
- A Novel Statistical Model to Estimate Host Genetic Effects Affecting Disease Transmission.Genetics · 2015Article
- Genome-wide identification of copy number variations between two chicken lines that differ in genetic resistance to Marek's disease.BMC genomics · 2015Article
- Article
- Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.eLife · 2015Article
- Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marek's disease (MD) is a lymphoproliferative disease caused by the MD virus (MDV), which costs the poultry industry nearly $1 billion annually. To identify quantitative trait loci (QTL) affecting MD susceptibility, the inbred lines 6(3) (MD resistant) and 7(2) (MD susceptible) were mated to create more than 300 F2 chickens. The F2 chickens were challenged with MDV JM strain, moderately virulent) at 1 wk of age and assessed for MD susceptibility. The QTL analysis was divided into three stages. In stage 1, 65 DNA markers selected from the chicken genetic maps were typed on the 40 most MD-susceptible and the 40 most MD-resistant F2 chickens, and 21 markers residing near suggestive QTL were revealed by analysis of variance (ANOVA). In stage 2, the suggestive markers plus available flanking markers were typed on 272 F2 chickens, and three suggestive QTL were identified by ANOVA. In stage 3, using the interval mapping program Map Manager and permutation tests, two significant and two suggestive MD QTL were identified on four chromosomal subregions. Three to five loci collected explained between 11 and 23% of the phenotypic MD variation, or 32-68% of the genetic variance. This study constitutes the first report in the domestic chicken on the mapping of non-major histocompatibility complex QTL affecting MD susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.