ArticleGenetics1998
Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 79 citations in OpenAlex.
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- The activity of engrailed imaginal disc enhancers is modulated epigenetically by chromatin and autoregulation.PLoS genetics · 2023Article
- A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi.Genetics · 2023Article
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- Single-nucleus RNA-sequencing in pre-cellularization Drosophila melanogaster embryos.PloS one · 2022Article
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference.PLoS genetics · 2021Article
- Review
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- Opbp is a new architectural/insulator protein required for ribosomal gene expression.Nucleic acids research · 2017Article
- Article
- Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin.Genome research · 2015Article
- Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function.Cellular and molecular life sciences : CMLS · 2014Review
- Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.Epigenetics · 2014Article
- The Drosophila eve insulator Homie promotes eve expression and protects the adjacent gene from repression by polycomb spreading.PLoS genetics · 2013Article
- New properties of Drosophila scs and scs' insulators.PloS one · 2013Article
- The complex transcription regulatory landscape of our genome: control in three dimensions.The EMBO journal · 2011Review
- A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogaster and vertebrates.Molecular and cellular biology · 2011Article
- E(y)2/Sus1 is required for blocking PRE silencing by the Wari insulator in Drosophila melanogaster.Chromosoma · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The suppressor of Hairy-wing [SU(HW)] binding region disrupts communication between a large number of enhancers and promoters and protects transgenes from chromosomal position effects. These properties classify the SU(HW) binding region as an insulator. While enhancers are blocked in a general manner, protection from repressors appears to be more variable. In these studies, we address whether repression resulting from the Polycomb group genes can be blocked by the SU(HW) binding region. The effects of this binding region on repression established by an Ultrabithorax Polycomb group Response Element were examined. A transposon carrying two reporter genes, the yellow and white genes, was used so that repression and insulation could be assayed simultaneously. We demonstrate that the SU(HW) binding region is effective at preventing Polycomb group repression. These studies suggest that one role of the su(Hw) protein may be to restrict the range of action of repressors, such as the Polycomb group proteins, throughout the euchromatic regions of the genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.