ArticleGenetics1998
The role of gene conversion in determining sequence variation and divergence in the Est-5 gene family in Drosophila pseudoobscura.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Gene conversion and DNA sequence polymorphism in the sex-determination gene fog-2 and its paralog ftr-1 in Caenorhabditis elegans.Molecular biology and evolution · 2010Article
- Nonallelic gene conversion in the genus Drosophila.Genetics · 2010Article
- Birth and death of genes and functions in the beta-esterase cluster of Drosophila.Journal of molecular evolution · 2009Article
- Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.Molecular and cellular biology · 2004Article
- Dynamics of a human interparalog gene conversion hotspot.Genome research · 2004Article
- Article
- Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster.Journal of genetics · 2003Article
- Article
- Contrasting patterns of nonneutral evolution in proteins encoded in nuclear and mitochondrial genomes.Genetics · 2000Article
- Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Nucleotide sequences of eight Est-5A and Est-5C genes corresponding to previously sequenced Est-5B genes in Drosophila pseudoobscura were determined to compare patterns of polymorphism and divergence among members of this small gene family. The three esterase genes were also sequenced from D. persimilis and D. miranda for interspecific comparisons. The data provide evidence that gene conversion between loci contributes to polymorphism and to the homogenization of the Est5 genes. For Est-5B, which encodes one of the most highly polymorphic proteins in Drosophila, 12% of the segregating amino acid variants appear to have been introduced via gene conversion from other members of the gene family. Interlocus gene conversion can also explain high sequence similarity, especially at synonymous sites, between Est-5B and Est-5A. Tests of neutrality using interspecific comparisons show that levels of polymorphism conform to neutral expectations at each Est-5 locus. However, McDonald-Kreitman tests based on intraspecific gene comparisons indicate that positive selection on amino acids has accompanied Est-5 gene duplication and divergence in D. pseudoobscura.
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Registered trials
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