ArticleGenetics1998
An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Phosphate Homeostasis - A Vital Metabolic Equilibrium Maintained Through the INPHORS Signaling Pathway.Frontiers in microbiology · 2020Review
- Phosphorylation of the Gα protein Gpa2 promotes protein kinase A signaling in yeast.The Journal of biological chemistry · 2019Article
- Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.BMC genomics · 2017Article
- Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.Molecular and cellular biochemistry · 2014Article
- The observation of plcA mutation and localization in Aspergillus nidulans.Journal of microbiology (Seoul, Korea) · 2014Article
- Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Genetics · 2012Article
- Acid phosphatases of budding yeast as a model of choice for transcription regulation research.Enzyme research · 2011Article
- Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae.Current genetics · 2010Review
- Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16.PloS one · 2008Article
- Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae.Eukaryotic cell · 2008Article
- Positive feedback regulates switching of phosphate transporters in S. cerevisiae.Molecular cell · 2007Article
- Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.Science (New York, N.Y.) · 2007Article
- Rb, whi it's not just for metazoans anymore.Oncogene · 2006Review
- The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses.Current genetics · 2005Article
- Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.The Biochemical journal · 2004Article
- Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast.Current genetics · 2004Article
- Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain.Molecular and cellular biology · 2001Article
- New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.Molecular biology of the cell · 2000Article
- Phospholipase C is involved in kinetochore function in Saccharomyces cerevisiae.Molecular and cellular biology · 2000Article
- Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The PLC1 gene product of Saccharomyces cerevisiae is a homolog of the delta isoform of mammalian phosphoinositide-specific phospholipase C (PI-PLC). We found that two genes (SPL1 and SPL2), when overexpressed, can bypass the temperature-sensitive growth defect of a plc1delta cell. SPL1 is identical to the PHO81 gene, which encodes an inhibitor of a cyclin (Pho80p)-dependent protein kinase (Pho85p) complex (Cdk). In addition to overproduction of Pho81p, two other conditions that inactivate this Cdk, a cyclin (pho80delta) mutation and growth on low-phosphate medium, also permitted growth of plc1delta cells at the restrictive temperature. Suppression of the temperature sensitivity of plc1delta cells by pho80delta does not depend upon the Pho4p transcriptional regulator, the only known substrate of the Pho80p/Pho85p Cdk. The second suppressor, SPL2, encodes a small (17-kD) protein that bears similarity to the ankyrin repeat regions present in Pho81p and in other known Cdk inhibitors. Both pho81delta and spl2delta show a synthetic phenotype in combination with plc1delta. Unlike single mutants, plc1delta pho81delta and plc1delta spl2delta double mutants were unable to grow on synthetic complete medium, but were able to grow on rich medium.
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