ArticleBritish journal of cancer1998
Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response.Scientific reports · 2019Article
- The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer.Oncotarget · 2015Article
- Article
- Polysaccharide K suppresses angiogenesis in colon cancer cells.Experimental and therapeutic medicine · 2012Article
- MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer.International journal of oncology · 2012Article
- Novel roles for Slits and netrins: axon guidance cues as anticancer targets?Nature reviews. Cancer · 2011Review
- Colorectal carcinogenesis: Review of human and experimental animal studies.Journal of carcinogenesis · 2009Article
- Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers.British journal of cancer · 2005Review
- Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature.International journal of colorectal disease · 2004Review
- Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis.Digestive diseases and sciences · 2001Article
- Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue.Journal of clinical pathology · 2001Article
- Loss of DCC gene expression during ovarian tumorigenesis: relation to tumour differentiation and progression.British journal of cancer · 2000Article
- Article
- DCC expression is related to mucinous differentiation but not changes in expression of p21(WAF1/Cip1) and p27Kip1, apoptosis, cell proliferation and human papillomavirus infection in uterine cervical adenocarcinomas.British journal of cancer · 1999Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a bacterial fusion protein, a deleted colorectal carcinoma (DCC)-specific monoclonal antibody (MAb) 127-22 was established. Although MAb 127-22 reacted with almost all normal tissues, it did not react or only weakly reacted with many cancer cell lines, including colonic cancer lines, in flow cytometry. In Western immunoblots, the MAb reacted with a single 190-kDa molecule in a myeloma line Ara-10 extract. This component was scarcely detected in colonic cancer cell lines. Immunoblots of samples from 25 pairs of colonic cancers and adjacent normal tissues and from five adenoma tissues revealed that all normal colonic and adenoma tissues significantly expressed the DCC protein, whereas colonic cancer tissues showed poor expression. These results indicate not only deletion of and lowered mRNA expression of the DCC gene, but also marked reduction of DCC protein occurred in colonic cancer tissues. In addition, colonic cancer patients with liver metastasis expressed significantly lower levels of DCC than those without, suggesting the prognostic value of DCC expression.
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