ArticleThe Histochemical journal1997
Application of computer image analysis in endocrine cell quantification.
Article in The Histochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 47 citations in OpenAlex.
- Possible Mechanisms Underlying the Effects of Fecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2026Article
- Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.Molecular medicine reports · 2017Article
- Endocrine cells in the ileum of patients with irritable bowel syndrome.World journal of gastroenterology · 2014Article
- Loss of gastric interstitial cells of Cajal in patients with hereditary transthyretin amyloidosis.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2013Article
- Chromogranin A cell density as a diagnostic marker for lymphocytic colitis.Digestive diseases and sciences · 2012Article
- Improving evaluation of the distribution and density of immunostained cells in breast cancer using computerized video image analysis.Cancer management and research · 2011Article
- Validation and use of a computer-assisted counting procedure to quantify BrdU-labeled proliferating cells in the early postnatal mouse hippocampus.Journal of neuroscience methods · 2008Article
- Gastrointestinal endocrine cells in an animal model for human type 2 diabetes.Digestive diseases and sciences · 1999Article
- Antral endocrine cells in nonobese diabetic mice.Digestive diseases and sciences · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computer image analysis was applied for quantifying endocrine cells by using an automatic standard sequence analysis operation. Two parameters were used, namely the number of cells per mm3 of epithelial cells and the cell secretory index (the volume of the immunoreactive secretory granules per cell). The first indicates the variation in the anatomical peptide-producing unit and the second the synthesis and secretion activity of the cell. The endocrine cells chosen in this study were chromogranin-immunoreactive cells and secretin-immunoreactive cells in the human duodenum. The measurements were made by five different investigators with different backgrounds in order to evaluate the effect of the intra- and inter-individual variation. This study showed that the intra- and inter-individual variation had no impact on the results. Comparisons with the classical point-counting method considered to be easy and most efficient in volumetry showed that the present approach is between two and three times faster and less strenuous for the performer. It is concluded that this approach seems to be suitable for adaptation in morphometric studies when information is required about the changes in the number of endocrine cells and about changes in secretory activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.