ArticleThe Journal of cell biology1998
A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 131 citations in OpenAlex.
- No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo.Current topics in developmental biology · 2025Review
- Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.Molecular biology of the cell · 2015Article
- A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability.European journal of human genetics : EJHG · 2015Article
- Article
- Microtubule guidance tested through controlled cell geometry.Journal of cell science · 2012Article
- Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The spectraplakin Short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network.Molecular biology of the cell · 2010Article
- Unconventional myosins acting unconventionally.Trends in cell biology · 2009Review
- Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.Human molecular genetics · 2009Article
- A dual role for actin and microtubule cytoskeleton in the transport of Golgi units from the nurse cells to the oocyte across ring canals.Molecular biology of the cell · 2009Article
- Myosin VI is required for targeted membrane transport during cytokinesis.Molecular biology of the cell · 2007Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
- Association of six YFP-myosin XI-tail fusions with mobile plant cell organelles.BMC plant biology · 2007Article
- The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.Genes & development · 2005Article
- Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them.Protoplasma · 2005Article
- Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.The Journal of cell biology · 2005Article
- Myosin VI: cellular functions and motor properties.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Review
- Linkage of schizophrenia with chromosome 1q loci in Taiwanese families.Molecular psychiatry · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordination of cellular organization requires the interaction of the cytoskeletal filament systems. Recently, several lines of investigation have suggested that transport of cellular components along both microtubules and actin filaments is important for cellular organization and function. We report here on molecules that may mediate coordination between the actin and microtubule cytoskeletons. We have identified a 195-kD protein that coimmunoprecipitates with a class VI myosin, Drosophila 95F unconventional myosin. Cloning and sequencing of the gene encoding the 195-kD protein reveals that it is the first homologue identified of cytoplasmic linker protein (CLIP)-170, a protein that links endocytic vesicles to microtubules. We have named this protein D-CLIP-190 (the predicted molecular mass is 189 kD) based on its similarity to CLIP-170 and its ability to cosediment with microtubules. The similarity between D-CLIP-190 and CLIP-170 extends throughout the length of the proteins, and they have a number of predicted sequence and structural features in common. 95F myosin and D-CLIP-190 are coexpressed in a number of tissues during embryogenesis in Drosophila. In the axonal processes of neurons, they are colocalized in the same particulate structures, which resemble vesicles. They are also colocalized at the posterior pole of the early embryo, and this localization is dependent on the actin cytoskeleton. The association of a myosin and a homologue of a microtubule-binding protein in the nervous system and at the posterior pole, where both microtubule and actin-dependent processes are known to be important, leads us to speculate that these two proteins may functionally link the actin and microtubule cytoskeletons.
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