ArticleThe American journal of pathology1998
Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipients.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 90 citations in OpenAlex.
- Neointimal hyperplasia after endoluminal injury in mice is dependent on tissue factor- and angiopoietin-2 dependent interferon gamma production by fibrocytes and macrophages.Frontiers in immunology · 2024Article
- Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution.Frontiers in immunology · 2023Article
- Immunogenetics of new onset diabetes after transplantation in Kuwait.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Axl modulates immune activation of smooth muscle cells in vein graft remodeling.American journal of physiology. Heart and circulatory physiology · 2015Article
- Mouse models for graft arteriosclerosis.Journal of visualized experiments : JoVE · 2013Article
- CD28 family and chronic rejection: "to belatacept...And beyond!".Journal of transplantation · 2012Article
- AIP1 in graft arteriosclerosis.Trends in cardiovascular medicine · 2011Review
- AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion.Circulation research · 2011Article
- Innate immunity and monocyte-macrophage activation in atherosclerosis.Journal of inflammation (London, England) · 2011Article
- Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.Journal of biomedical science · 2009Article
- Cardiac allograft vasculopathy: the Achilles' heel of long-term survival after cardiac transplantation.Current atherosclerosis reports · 2006Review
- The link between IFN-gamma and allograft arteriopathy: is the answer NO?The Journal of clinical investigation · 2004Review
- Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis.The Journal of experimental medicine · 2002Article
- Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis.The American journal of pathology · 2001Article
- Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection.The Journal of clinical investigation · 1999Article
- Ultrastructure of rat aortic grafts.Folia microbiologica · 1999Article
- Leukocyte-suppressing influences of interleukin (IL)-10 in cardiac allografts: insights from IL-10 knockout mice.The American journal of pathology · 1998Article
- Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma.The American journal of pathology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the functional role of interferon (IFN)-gamma in transplant arteriosclerosis, BALB/c hearts were transplanted in immunosuppressed C57BL/6J recipients with (n = 10) or without (n = 10) targeted IFN-gamma gene deletion. In 55-day heart allografts, IFN-gamma deficiency resulted in a significant decrease in vascular thickening. The severity of intimal thickening measured as the percentage of luminal occlusion (mean +/- SEM) in all elastin stained vessels (n = 410) decreased from 37+/-5% in wild-type recipients to 18+/-5% in IFN-gamma -/- recipients (P < 0.005). In the few diseased vessels in grafts from IFN-gamma -/- recipients, the neointima was more cellular with a 90% increase in the nuclear density. This finding correlated with a 50% reduction in fibrosis estimated by alpha-smooth muscle actin cell accumulation in the neointima. The reduction in severity and altered composition of vascular thickening in grafts from IFN-gamma -/- recipients shows that IFN-gamma contributes to arteriosclerotic development following transplantation.
Indexed as
Identifiers
9466561PMC1857959W2244015171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.