ArticleThe Histochemical journal
Ultrastructural localization of osteopontin immunoreactivity in phagolysosomes and secretory granules of cells in human intestine.
Article in The Histochemical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 21 citations in OpenAlex.
- Osteopontin: participation in inflammation or mucosal protection in inflammatory bowel diseases?Digestive diseases and sciences · 2013Article
- Osteopontin biomarker in inflammatory bowel disease, animal models and target for drug discovery.Digestive diseases and sciences · 2012Article
- Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions.The American journal of pathology · 2010Article
- The cytokine osteopontin modulates the severity of rotavirus diarrhea.Journal of virology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A post-embedding ultrastructural immunogold method was used to detect osteopontin in human intestinal biopsies with special emphasis on secretory and phagocytic organelles. Osteopontin immunoreactivity was localized to phagolysosomes of macrophages, fibroblasts, absorptive epithelial cells of the small intestine and Paneth cells. The mucigen secretory granules and Golgi structures of mucous epithelial cells of the small intestinal epithelium contained osteopontin, but secretory granules of numerous other cells, including Paneth cells, did not. Extracellular and phagocytosed Tropheryma whippelii within macrophage phagolysosomes also bound osteopontin. These localizations are supportive of a role for osteopontin in phagocytic and some secretory cell functions in human intestine.
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Registered trials
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