ArticleProceedings of the National Academy of Sciences of the United States of America1998
Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 102 citations in OpenAlex.
- Inhibitors of Cyclophilin A: Current and Anticipated Pharmaceutical Agents for Inflammatory Diseases and Cancers.Molecules (Basel, Switzerland) · 2024Review
- Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.Journal of virology · 2023Review
- Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.Cell reports · 2020Article
- Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes.PLoS pathogens · 2017Article
- Molecular Architecture of the Retroviral Capsid.Trends in biochemical sciences · 2016Review
- Extracellular cyclophilins in health and disease.Biochimica et biophysica acta · 2015Review
- Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.Microbiology and molecular biology reviews : MMBR · 2014Review
- Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.The Journal of biological chemistry · 2014Article
- Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Review
- Conformational plasticity of an enzyme during catalysis: intricate coupling between cyclophilin A dynamics and substrate turnover.Biophysical journal · 2013Article
- TLR2 activation enhances HIV nuclear import and infection through T cell activation-independent and -dependent pathways.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The Lymantria dispar IPLB-Ld652Y cell line transcriptome comprises diverse virus-associated transcripts.Viruses · 2011Article
- Contribution of cyclophilin A to the regulation of inflammatory processes in rheumatoid arthritis.Journal of clinical immunology · 2010Article
- Unfolding the relationship between secreted molecular chaperones and macrophage activation states.Cell stress & chaperones · 2009Review
- Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus.Journal of molecular biology · 2008Article
- CD147 immunoglobulin superfamily receptor function and role in pathology.Experimental and molecular pathology · 2007Review
- CD147 stimulates HIV-1 infection in a signal-independent fashion.Biochemical and biophysical research communications · 2007Article
- A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide.European biophysics journal : EBJ · 2007Article
- Plunder and stowaways: incorporation of cellular proteins by enveloped viruses.Journal of virology · 2005Review
- Roles of cyclophilins in cancers and other organ systems.World journal of surgery · 2005Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated into HIV-1 virions and its incorporation essential for viral infectivity. Here we present evidence supporting a role for viral-associated CyPA in the early events of HIV-1 infection. We report that HIV-1 infection of primary peripheral blood mononuclear cells can be inhibited by: (i) an excess of exogenously added CyPA; (ii) a CsA analogue unable to enter the cells; (iii) neutralizing antibodies to CyPA. Taken together with our observations that recombinant CyPA-induced mobilization of calcium in immortalized, as well as primary, CD4+ T lymphocytes, and that incubation of T cells with iodinated CyPA, followed by chemical cross-linking, resulted in the formation of a high molecular mass complex on the cell surface, these results suggest that HIV-1-associated CyPA mediates an early event in viral infection via interaction with a cellular receptor. This interaction may present a target for anti-HIV therapies and vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.