ArticleProceedings of the National Academy of Sciences of the United States of America1998
Mapping a disease locus by allelic association.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CHROMSCAN: genome-wide association using a linkage disequilibrium map.Journal of human genetics · 2008Pooled it
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- Homozygosity and risk of childhood death due to invasive bacterial disease.BMC medical genetics · 2009Article
- Allelic association: linkage disequilibrium structure and gene mapping.Molecular biotechnology · 2009Review
- Drug resistance and genetic mapping in Plasmodium falciparum.Current genetics · 2008Review
- Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects.Journal of human genetics · 2008Article
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
- Mapping a gene for rheumatoid arthritis on chromosome 18q21.BMC proceedings · 2007Article
- Genome scanning by composite likelihood.American journal of human genetics · 2007Article
- Human imprinted chromosomal regions are historical hot-spots of recombination.PLoS genetics · 2006Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- Fifty years of genetic epidemiology, with special reference to Japan.Journal of human genetics · 2006Review
- A map of the human genome in linkage disequilibrium units.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allelic association provides a means to map disease genes that, in a dense map of polymorphic markers, has considerably higher resolution than linkage methods. We describe here a composite likelihood estimate of location for a disease gene against a high-resolution marker map by using allele frequencies at linked loci. Data may be family-based, as in the transmission disequilibrium test, or from a case-control study. chi2 tests, logarithm of odds, standard errors, and information weights are provided. The method is illustrated by analysis of published cystic fibrosis haplotypes, in which DeltaF508 is more accurately localized than by other association studies. This differs from current approaches by adopting a more general Malecot model for isolation by distance, where distance here is between marker and disease locus, allowance for errors in the map and model, and freedom from assumptions about demography, systematic pressures, and the ratio of physical to genetic distance. When these assumptions are introduced the number of generations since the original mutation may be estimated, but this is not required to determine location and its standard error, so that evidence from allelic association may be efficiently combined with linkage evidence to identify a region for positional cloning of a disease gene.
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