ArticleProceedings of the National Academy of Sciences of the United States of America1998
An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 106 citations in OpenAlex.
- Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents.Frontiers in chemistry · 2022Review
- Article
- Hit the right spots: cell cycle control by phosphorylated guanosines in alphaproteobacteria.Nature reviews. Microbiology · 2017Review
- Homologues of Genetic Transformation DNA Import Genes Are Required for Rhodobacter capsulatus Gene Transfer Agent Recipient Capability Regulated by the Response Regulator CtrA.Journal of bacteriology · 2015Article
- Sinorhizobium meliloti CtrA Stability Is Regulated in a CbrA-Dependent Manner That Is Influenced by CpdR1.Journal of bacteriology · 2015Article
- Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein.Nature communications · 2015Article
- The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti.Molecular microbiology · 2013Article
- The Sinorhizobium meliloti sensor histidine kinase CbrA contributes to free-living cell cycle regulation.Microbiology (Reading, England) · 2013Article
- Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.PLoS computational biology · 2013Article
- Coordination of division and development influences complex multicellular behavior in Agrobacterium tumefaciens.PloS one · 2013Article
- The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus.Journal of bacteriology · 2012Article
- The architecture and conservation pattern of whole-cell control circuitry.Journal of molecular biology · 2011Article
- A cell-type-specific protein-protein interaction modulates transcriptional activity of a master regulator in Caulobacter crescentus.Molecular cell · 2010Article
- Polar remodeling and histidine kinase activation, which is essential for Caulobacter cell cycle progression, are dependent on DNA replication initiation.Journal of bacteriology · 2010Article
- The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis.BMC systems biology · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Polar localization of the CckA histidine kinase and cell cycle periodicity of the essential master regulator CtrA in Caulobacter crescentus.Journal of bacteriology · 2010Article
- Synchronization of chromosome dynamics and cell division in bacteria.Cold Spring Harbor perspectives in biology · 2010Review
- Dynamics of two Phosphorelays controlling cell cycle progression in Caulobacter crescentus.Journal of bacteriology · 2009Article
- Cellular polarity in prokaryotic organisms.Cold Spring Harbor perspectives in biology · 2009Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell differentiation and division in Caulobacter crescentus are regulated by a signal transduction pathway mediated by the histidine kinase DivJ and the essential response regulator DivK. Here we report genetic and biochemical evidence that the DivJ and DivK proteins function to control the activity of CtrA, a response regulator required for multiple cell cycle events, including flagellum biosynthesis, DNA replication, and cell division. Temperature-sensitive sokA (suppressor of divK) alleles were isolated as extragenic suppressors of a cold-sensitive divK mutation and mapped to the C terminus of the CtrA protein. The sokA alleles also suppress the lethal phenotype of a divK gene disruption and the cold-sensitive cell division phenotype of divJ mutants. The relationship between these signal transduction components and their target was further defined by demonstrating that the purified DivJ kinase phosphorylates CtrA, as well as DivK. Our studies also showed that phospho-CtrA activates transcription in vitro from the class II flagellar genes and that their promoters are recognized by the principal C. crescentus sigma factor sigma73. We propose that an essential signal transduction pathway mediated by DivJ, DivK, and CtrA coordinates cell cycle and developmental events in C. crescentus by regulating the level of CtrA phosphorylation and transcription from sigma73-dependent class II gene promoters. Our results suggest that an unidentified phosphotransfer protein or kinase (X) is responsible for phosphoryl group transfer to CtrA in the proposed DivJ --> DivK --> X --> CtrA phosphorelay pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.