ArticleThe Journal of experimental medicine1998
Acquisition of Ly49 receptor expression by developing natural killer cells.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 164 citations in OpenAlex.
- Ly49G, but not Ly49C/I, is dispensable for diverse antigen-specific memory NK cell responses in H-2d and H-2b mice.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Article
- Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.bioRxiv : the preprint server for biology · 2024Article
- Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules.Structure (London, England : 1993) · 2024Article
- Cis-regulatory evolution of the recently expanded Ly49 gene family.Nature communications · 2024Article
- NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection.The Journal of experimental medicine · 2021Article
- Functional Characterization of Ly49Frontiers in immunology · 2020Article
- Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.Nature communications · 2019Article
- Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function.Particle and fibre toxicology · 2017Article
- Expression of CD226 is associated to but not required for NK cell education.Nature communications · 2017Article
- Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.PLoS biology · 2016Article
- Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- NK cell tolerance as the final endorsement of prenatal tolerance after in utero hematopoietic cellular transplantation.Frontiers in pharmacology · 2015Review
- Pro-inflammatory role of natural killer cells in the development of allergic airway disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- The unique neonatal NK cells: a critical component required for neonatal autoimmune disease induction by maternal autoantibody.Frontiers in immunology · 2014Review
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Article
- Multiple levels of chemokine receptor regulation in the control of mouse natural killer cell development.Frontiers in immunology · 2014Review
- Location and cellular stages of natural killer cell development.Trends in immunology · 2013Review
- Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The formation of the repertoire of mouse natural killer (NK) cell receptors for major histocompatibility complex (MHC) class I molecules was investigated by determining the developmental pattern of Ly49 receptor expression. During the first days after birth, few or no splenic NK cells express Ly49A, Ly49C, Ly49G2, or Ly49I receptors. The proportion of Ly49+ splenic NK cells gradually rises to adult levels during the first 6-8 wk of life. The appearance of appreciable numbers of splenic Ly49+ NK cells coincides with the appearance of NK activity at 3-4 wk. After in vivo transfer, NK cells not expressing specific Ly49 receptors can give rise to NK cells that do, and cells expressing one of these four Ly49 receptors can give rise to cells expressing others. Once initiated, expression of a Ly49 receptor is stable for at least 10 d after in vivo transfer. Hence, initiation of Ly49 receptor expression occurs successively. Interestingly, expression of one of the receptors tested, Ly49A, did not occur after in vivo transfer of Ly49A- cells. One possible explanation for these data is that the order of Ly49 receptor expression by NK cells is nonrandom. The results provide a framework for evaluating models of NK cell repertoire formation, and how the repertoire is molded by host class I MHC molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.