ArticleThe Journal of experimental medicine1998
Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- Retention of Donor T Cells in Lymphohematopoietic Tissue and Augmentation of Tissue PD-L1 Protection for Prevention of GVHD While Preserving GVL Activity.Frontiers in immunology · 2022Review
- Type II NKT Cells and Their Emerging Role in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset.Immunogenetics · 2016Review
- Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.European journal of immunology · 2015Article
- The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions.Frontiers in immunology · 2015Review
- Different subsets of natural killer T cells may vary in their roles in health and disease.Immunology · 2014Review
- Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus.Arthritis research & therapy · 2013Article
- NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.Current immunology reviews · 2012Article
- Modulatory function of invariant natural killer T cells in systemic lupus erythematosus.Clinical & developmental immunology · 2012Review
- Beta-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus.Clinical immunology (Orlando, Fla.) · 2009Article
- The role of NKT cells in tumor immunity.Advances in cancer research · 2008Review
- Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies.European journal of immunology · 2008Article
- The natural killer T lymphocyte: a player in the complex regulation of autoimmune diabetes in non-obese diabetic mice.Clinical and experimental immunology · 2006Review
- Human innate B cells: a link between host defense and autoimmunity?Springer seminars in immunopathology · 2005Review
- MHC-dependent and -independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T-cell receptor type.Immunology · 2003Article
- Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.The Journal of clinical investigation · 2003Article
- Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families.The Journal of experimental medicine · 2001Article
- Immune privilege: keeping an eye on natural killer T cells.The Journal of experimental medicine · 1999Article
- Molecular recognition of lipid antigens by T cell receptors.The Journal of experimental medicine · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4+, CD8+, or CD4-CD8- T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti-double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4-CD8- T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-gamma and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-gamma or IL-10.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.