ArticleThe Journal of experimental medicine1998
Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 84 citations in OpenAlex.
- Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies' immunogenicity.Frontiers in immunology · 2025Review
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- DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.The Journal of experimental medicine · 2017Article
- FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- The Role of FcRn in Antigen Presentation.Frontiers in immunology · 2014Review
- Cross-presentation of IgG-containing immune complexes.Cellular and molecular life sciences : CMLS · 2013Review
- B cells as effectors and regulators of sex-biased arthritis.Autoimmunity · 2012Review
- Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice.Molecular immunology · 2007Article
- Preclinical evaluation of autologous dendritic cells transfected with mRNA or loaded with apoptotic cells for immunotherapy of high-risk neuroblastoma.Cancer gene therapy · 2005Article
- Autoantibodies to vascular smooth muscle are pathogenic for vasculitis.The American journal of pathology · 2005Article
- Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.Infection and immunity · 2005Article
- Inhibitory Fc gamma receptors: from gene to disease.Journal of clinical immunology · 2004Review
- Article
- Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo.The Journal of experimental medicine · 2002Article
- Immune complex-mediated antigen presentation induces tumor immunity.The Journal of clinical investigation · 2002Article
- Antitumor monoclonal antibodies enhance cross-presentation ofcCellular antigens and the generation of myeloma-specific killer T cells by dendritic cells.The Journal of experimental medicine · 2002Article
- Interleukin 4-producing CD4 T cells arise from different precursors depending on the conditions of antigen exposure in vivo.The Journal of experimental medicine · 2000Article
- Presentation of antigen in immune complexes is boosted by soluble bacterial immunoglobulin binding proteins.The Journal of experimental medicine · 1999Article
- Purification of intracellular compartments involved in antigen processing: a new method based on magnetic sorting.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell receptors on CD4(+) lymphocytes recognize antigen-derived peptides presented by major histocompatibility complex (MHC) class II molecules. A very limited set of peptides among those that may potentially bind MHC class II is actually presented to T lymphocytes. We here examine the role of two receptors mediating antigen internalization by antigen presenting cells, type IIb2 and type III receptors for IgG (FcgammaRIIb2 and FcgammaRIII, respectively), in the selection of peptides for presentation to T lymphocytes. B lymphoma cells expressing recombinant FcgammaRIIb2 or FcgammaRIII were used to assess the presentation of several epitopes from two different antigens. 4 out of the 11 epitopes tested were efficiently presented after antigen internalization through FcgammaRIIb2 and FcgammaRIII. In contrast, the 7 other epitopes were efficiently presented only when antigens were internalized through FcgammaRIII, but not through FcgammaRIIb2. The capacity to present these latter epitopes was transferred to a tail-less FcgammaRIIb2 by addition of the FcgammaRIII-associated gamma chain cytoplasmic tail. Mutation of a single leucine residue at position 35 of the gamma chain cytoplasmic tail resulted in the selective loss of presentation of these epitopes. Therefore, the nature of the receptor that mediates internalization determines the selection of epitopes presented to T lymphocytes within single protein antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.