ArticleThe EMBO journal1998
Synapsin I is structurally similar to ATP-utilizing enzymes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 131 citations in OpenAlex.
- An unsuspected physiological role for mGluRIII glutamate receptors in hippocampal area CA1.Cell reports · 2026Article
- Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles.Nature communications · 2024Article
- Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Phase separation at the synapse.Nature neuroscience · 2020Review
- Autoantibodies to synapsin I sequestrate synapsin I and alter synaptic function.Cell death & disease · 2019Article
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- Article
- Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation.Neurochemical research · 2019Article
- Review
- Large-scale computational drug repositioning to find treatments for rare diseases.NPJ systems biology and applications · 2018Article
- Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase.Scientific reports · 2017Article
- Review
- Calcium-Dependent and Synapsin-Dependent Pathways for the Presynaptic Actions of BDNF.Frontiers in cellular neuroscience · 2017Article
- Synapsin Isoforms and Synaptic Vesicle Trafficking.Molecules and cells · 2015Review
- ATP binding to synaspsin IIa regulates usage and clustering of vesicles in terminals of hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The biosynthesis of UDP-d-FucNAc-4N-(2)-oxoglutarate (UDP-Yelosamine) in Bacillus cereus ATCC 14579: Pat and Pyl, an aminotransferase and an ATP-dependent Grasp protein that ligates 2-oxoglutarate to UDP-4-amino-sugars.The Journal of biological chemistry · 2014Article
- Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Involvement of synaptic genes in the pathogenesis of autism spectrum disorders: the case of synapsins.Frontiers in pediatrics · 2014Review
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- The ATP-grasp enzymes.Bioorganic chemistry · 2011Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapsins are abundant synaptic vesicle proteins with an essential regulatory function in the nerve terminal. We determined the crystal structure of a fragment (synC) consisting of residues 110-420 of bovine synapsin I; synC coincides with the large middle domain (C-domain), the most conserved domain of synapsins. SynC molecules are folded into compact domains and form closely associated dimers. SynC monomers are strikingly similar in structure to a family of ATP-utilizing enzymes, which includes glutathione synthetase and D-alanine:D-alanine ligase. SynC binds ATP in a Ca2+-dependent manner. The crystal structure of synC in complex with ATPgammaS and Ca2+ explains the preference of synC for Ca2+ over Mg2+. Our results suggest that synapsins may also be ATP-utilizing enzymes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.