ArticleAmerican journal of human genetics1998
Likelihood analysis of disequilibrium mapping, and related problems.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 95 citations in OpenAlex.
- Founder mutation in the PMM2 promotor causes hyperinsulinemic hypoglycaemia/polycystic kidney disease (HIPKD).Molecular genetics & genomic medicine · 2021Article
- Founder mutation in KCNJ10 in Pakistani patients with EAST syndrome.Molecular genetics & genomic medicine · 2016Article
- Review
- The USH2A c.2299delG mutation: dating its common origin in a Southern European population.European journal of human genetics : EJHG · 2010Article
- Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping.American journal of human genetics · 2005Article
- Article
- Mutation history of the roma/gypsies.American journal of human genetics · 2004Article
- Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis.Human genetics · 2004Article
- A 122.5-kilobase deletion of the P gene underlies the high prevalence of oculocutaneous albinism type 2 in the Navajo population.American journal of human genetics · 2003Article
- Score tests for association between traits and haplotypes when linkage phase is ambiguous.American journal of human genetics · 2002Article
- Molecular analysis of the beta-globin gene cluster in the Niokholo Mandenka population reveals a recent origin of the beta(S) Senegal mutation.American journal of human genetics · 2002Article
- Bayesian analysis of haplotypes for linkage disequilibrium mapping.Genome research · 2001Article
- Article
- High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence.American journal of human genetics · 2001Article
- Recent origin and spread of a common Lithuanian mutation, G197del LDLR, causing familial hypercholesterolemia: positive selection is not always necessary to account for disease incidence among Ashkenazi Jews.American journal of human genetics · 2001Article
- Multipoint linkage-disequilibrium-mapping approach based on the case-parent trio design.American journal of human genetics · 2001Article
- Allele age and a test for selection on rare alleles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Article
- Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.American journal of human genetics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this paper a theory is developed that provides the sampling distribution of alleles at a diallelic marker locus closely linked to a low-frequency allele that arose as a single mutant. The sampling distribution provides a basis for maximum-likelihood estimation of either the recombination rate, the mutation rate, or the age of the allele, provided that the two other parameters are known. This theory is applied to (1) the data of Hästbacka et al., to estimate the recombination rate between a locus associated with diastrophic dysplasia and a linked RFLP marker; (2) the data of Risch et al., to estimate the age of a presumptive allele causing idiopathic distortion dystonia in Ashkenazi jews; and (3) the data of Tishkoff et al., to estimate the date at which, at the CD4 locus, non-African lineages diverged from African lineages. We conclude that the extent of linkage disequilibrium can lead to relatively accurate estimates of recombination and mutation rates and that those estimates are not very sensitive to parameters, such as the population age, whose values are not known with certainty. In contrast, we also conclude that, in many cases, linkage disequilibrium may not lead to useful estimates of allele age, because of the relatively large degree of uncertainly in those estimates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.