ArticleJournal of clinical pathology1997
Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers.
Article in Journal of clinical pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- Role of New Anatomy, Biliopancreatic Reflux, and Helicobacter Pylori Status in Postgastrectomy Stump Cancer.Journal of clinical medicine · 2022Review
- ZC3H15 promotes gastric cancer progression by targeting the FBXW7/c-Myc pathway.Cell death discovery · 2022Article
- Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions.International journal of molecular sciences · 2021Review
- Premalignant lesions and gastric cancer: Current understanding.World journal of gastrointestinal oncology · 2019Review
- Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer.PloS one · 2017Article
- Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis.BioMed research international · 2015Review
- Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis.Surgery · 2010Article
- Relationship between the histological type of initial lesions and the risk for the development of remnant gastric cancers after gastrectomy for synchronous multiple gastric cancers.World journal of surgery · 2010Article
- Cellular and molecular aspects of gastric cancer.World journal of gastroenterology · 2006Review
- Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms.World journal of gastroenterology · 2006Review
- Mucin phenotypic expression and p53 gene abnormality of gastric super-minute well-differentiated adenocarcinoma: re-evaluation with relationship between histogenesis of well-differentiated adenocarcinoma and intestinal metaplasia in distal stomach.Journal of carcinogenesis · 2005Article
- Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy.Journal of clinical pathology · 2005Review
- Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells.The American journal of pathology · 2003Article
- Article
- Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitis.Journal of clinical pathology · 2001Article
- Incomplete gastric metaplasia in children with insulin-dependent diabetes mellitus and celiac disease. An ultrastructural study.BMC clinical pathology · 2001Article
- Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer.The American journal of pathology · 2000Article
- Variability in the interpretation of microsatellite patterns with different electrophoretic conditions.Molecular pathology : MP · 1999Article
- HLA-B*27 typing by sequence specific amplification without DNA extraction.Molecular pathology : MP · 1999Article
- Association of p53 genomic instability with the glutathione S-transferase null genotype in gastric cancer in the Portuguese population.Molecular pathology : MP · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the presence of genetic instability in precancerous lesions of the stomach.
methodsFifteen cases of sporadic gastric cancers with a background of intestinal metaplasia were studied by microsatellite assay at nine loci. Altered metaplastic mucosa was microdissected, reconstructed topographically, and examined immunohistochemically with an anti-p53 antibody, comparing its positive area with foci of microsatellite instability in each individual.
resultsAlterations at one or more loci were observed in seven of 15 cancers (46.7%) and four of 15 intestinal metaplasias (26.7%). Two cases of replication error positive phenotype had no microsatellite alterations in their metaplastic mucosa. All the microsatellite alterations in the metaplastic mucosa were restricted to incomplete-type intestinal metaplasia around the respective cancers. Moreover, in one case, an identical pattern of microsatellite alteration was detected in the cancer tissue and in the adjacent metaplastic mucosa, suggesting the sequential development of gastric cancer from intestinal metaplasia. Frequent alteration was found at the locus D1S191 (1q), indicating that this locus might be altered early in the development of intestinal-type gastric cancer. No significant association between microsatellite instability and p53 immunoreactivity was observed in the cases examined.
conclusionThese results indicate that microsatellite instability may be an early event in stomach carcinogenesis, especially in intestinal-type cancers.
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