ArticleGut1997
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin.
Article in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Small bowel injury induced by selective cyclooxygenase-2 inhibitors: a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam.Journal of gastroenterology · 2012Trial
- Enhancing radiologist's detection: an imaging-based grading system for differentiating Crohn's disease from ulcerative colitis.BMC medicine · 2024Article
- Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.ILAR journal · 2021Review
- Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding.World journal of gastroenterology · 2014Article
- Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.World journal of gastroenterology · 2014Article
- Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2011Article
- Effects of Gum acacia aqueous extract on the histology of the intestine and enzymes of both the intestine and the pancreas of albino rats treated with Meloxicam.Pharmacognosy research · 2011Article
- Vulnerable sites and changes in mucin in the rat small intestine after non-steroidal anti-inflammatory drugs administration.Digestive diseases and sciences · 2010Article
- Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats.Digestive diseases and sciences · 2010Article
- Effects of indomethacin on the rat small intestinal mucosa: immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies.Journal of gastroenterology · 2009Article
- Nimesulide inhibits crypt epithelial cell proliferation at 6 hours in the small intestine in CD-1 mice.Digestive diseases and sciences · 2007Article
- Nimesulide alters cell recruitment into mitosis in murine intestinal crypts without influencing the cell production rate.Digestive diseases and sciences · 2007Article
- Endothelin-1 receptor antagonist (LU-135252) improves the microcirculation and course of TNBS colitis in rats.Digestive diseases and sciences · 2006Article
- Determining small bowel integrity following drug treatment.British journal of clinical pharmacology · 2003Review
- Mechanisms involved in the attenuation of intestinal toxicity induced by (S)-(+)-ketoprofen in re-fed rats.Digestive diseases and sciences · 2002Article
- 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors.Digestive diseases and sciences · 2002Article
- Effect of diet on changes in small intestinal blood flow following intracolonic administration of indomethacin to rats.Digestive diseases and sciences · 2001Article
- Vascular anatomy in gastrointestinal inflammation.Journal of clinical pathology · 1999Review
- Copper-indomethacinate associated with zwitterionic phospholipids prevents enteropathy in rats: effect on inducible NO synthase.Digestive diseases and sciences · 1999Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndomethacin induces ulceration in the rat jejunum with sparing of the ileum. The ulcers localise between vasa recta along the mesenteric margin of the bowel, observations that have not been fully explained.
aimTo examine the relationship between the localisation of experimental ulcers and the vascular anatomy of the rat small intestine.
methodsThe normal vascular anatomy of the rat jejunum and ileum was studied and compared using arterial carbon ink perfusion. The anatomical localisation of early and advanced lesions induced by indomethacin was examined with particular reference to the vasculature. Mucosal injury induced by feeding vessel ligation for 24 hours or brief ischaemia-reperfusion injury was examined. The existence of anatomically sensitive sites to indomethacin was tested in a two dose study.
resultsIn the rat jejunum, poorly vascularised sites along the mesenteric margin were highly susceptible to indomethacin induced injury, such sites being absent from the ileum. Villous contraction was a feature of both early indomethacin injury and ischaemia-reperfusion injury in the rat jejunum. Twenty four hour ligation of jejunal vasa brevia selectively induced ischaemic injury along the mesenteric margin. Two doses of indomethacin to rats did not induce greater injury than a single dose.
conclusionsResults support the hypothesis that the rat jejunum possesses vascularly compromised sites along the mesenteric margin that are susceptible to indomethacin induced injury. Indomethacin may cause ischaemia-reperfusion injury selectively at these sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.