ArticleThe Biochemical journal1998
Evidence that the E4 and FE4 esterase genes responsible for insecticide resistance in the aphid Myzus persicae (Sulzer) are part of a gene family.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Spread of a Single Superclone Drives Insecticide Resistance in Acyrthosiphon kondoi Across an Invasive Range.Molecular biology and evolution · 2025Article
- Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.Insect science · 2025Article
- Article
- A Comprehensive Transcriptomic and Proteomics Analysis of Candidate Secretory Proteins in Rose Grain Aphid,Current issues in molecular biology · 2024Article
- Article
- RNAseq-Based CarboxylesteraseInsects · 2024Article
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Epitranscriptomic regulation of insecticide resistance.Science advances · 2021Article
- UDP-Glycosyltransferases from the UGT344 Family Are Involved in Sulfoxaflor Resistance inInsects · 2021Article
- Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest.BMC genomics · 2020Article
- Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles.Insect science · 2019Article
- Differential gene expression in the evolution of sex pheromone communication in New Zealand's endemic leafroller moths of the genera Ctenopseustis and Planotortrix.BMC genomics · 2018Article
- Pyrethroid Acaricide Resistance Is Proportional to P-450 Cytochrome Oxidase Expression in the Cattle TickBioMed research international · 2018Article
- Transcriptome Analysis and Identification of Major Detoxification Gene Families and Insecticide Targets in Grapholita Molesta (Busck) (Lepidoptera: Tortricidae).Journal of insect science (Online) · 2017Article
- Bacterial Expression and Kinetic Analysis of Carboxylesterase 001D from Helicoverpa armigera.International journal of molecular sciences · 2016Article
- Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.Nature communications · 2016Article
- Anticipatory gene regulation driven by maternal effects in an insect-host system.Ecology and evolution · 2015Article
- Transcriptome analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection.PloS one · 2015Article
- Molecular and functional characterization of cDNAs putatively encoding carboxylesterases from the migratory locust, Locusta migratoria.PloS one · 2014Article
- The molecular genetics of insecticide resistance.Genetics · 2013Review
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2 authors.
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Abstract
The amplification of genes encoding the esterases E4 and FE4 is a widespread mechanism of insecticide resistance in the peach-potato aphid, Myzus persicae (Sulzer). We present evidence that in susceptible aphids the two genes are adjacent to each other in a head-to-tail arrangement with E4 upstream of FE4 and with approx. 19 kb of intervening sequence. There are also at least two other closely related sequences which might come from other members of an esterase gene family, in line with reports of other insect gene families encoding detoxifying enzymes. The close identity between E4 and FE4 genes indicates a recent duplication and divergence. The subsequent amplifications giving multiple copies of either E4 or FE4 must have involved two separate events, each probably occurring once and then being selected by insecticide exposure and spread by migration. The cloning of sequences upstream of the FE4 gene suggest, by comparison with E4, that the two genes are regulated in different ways. FE4 has sequences corresponding to a conventional promoter (TATA box and CAP site) that are not present in E4; on the other hand, FE4 lacks the CpG island present 5' of E4 genes that may control expression through changes in DNA methylation. The differences are likely to have occurred by the duplication event that gave rise to E4 and FE4 leading to different 5' sequences.
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