ArticleNucleic acids research1998
Identification of cis-acting elements in the SUC2 promoter of Saccharomyces cerevisiae required for activation of transcription.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- D-Xylose Sensing inInternational journal of molecular sciences · 2021Review
- Promoter Architecture and Promoter Engineering inMetabolites · 2020Review
- Article
- Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells That Maintains the Structure and Activity of Mig1 Protein Repressor Complex.The Journal of biological chemistry · 2016Article
- Invertase Suc2-mediated inulin catabolism is regulated at the transcript level in Saccharomyces cerevisiae.Microbial cell factories · 2015Article
- Dynamic regulation of gene expression using sucrose responsive promoters and RNA interference in Saccharomyces cerevisiae.Microbial cell factories · 2015Article
- Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome.The Journal of biological chemistry · 2014Article
- Carbon source dependent promoters in yeasts.Microbial cell factories · 2014Review
- Eco-evolutionary dynamics of complex social strategies in microbial communities.Communicative & integrative biology · 2014Review
- Multiway real-time PCR gene expression profiling in yeast Saccharomyces cerevisiae reveals altered transcriptional response of ADH-genes to glucose stimuli.BMC genomics · 2008Article
- Network motifs: structure does not determine function.BMC genomics · 2006Article
- Glucose signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae.Current genetics · 2003Review
- Mutations in GCR1 affect SUC2 gene expression in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2003Article
- Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.Molecular and cellular biology · 2001Article
- A two-hybrid system for transactivator bait proteins.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo.Molecular and cellular biology · 2001Article
- Article
- Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae.Genetics · 1998Article
- Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We analyzed the effects of site-directed mutations in the SUC2 promoter of Saccharomyces cerevisiae. Analyses were performed in wild-type as well as mig1 and tup1 mutant strains after the promoter mutants were reintroduced into the native SUC2 locus on the left arm of chromosome IX. Mutation of the two GC boxes revealed that these elements play two distinct roles: they are, as expected, required for Mig1-mediated repression but they are also necessary for activation of the SUC2 promoter in response to glucose limitation. The individual GC boxes are functionally redundant with regard to Mig1-mediated repression, however, only the upstream GC box is essential for high level expression of SUC2. Microccocal nuclease sensitivity of the SUC2 promoter in derepressed cells was reduced in the GC box mutant promoters, particularly in the vicinity of the TATA box. The difference in nuclease sensitivity between wild-type and GC box mutant promoters was not evident in tup1- cells. The formation of nuclease-resistant chromatin does not require the GC boxes, indicating that other cis-acting elements can serve to recruit the Ssn6-Tup1 co-repressor complex to the SUC2 promoter.
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