ArticleNucleic acids research1998
Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 77 citations in OpenAlex.
- HBO1, a MYSTerious KAT and its links to cancer.Biochimica et biophysica acta. Gene regulatory mechanisms · 2024Review
- Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function.Molecular cell · 2022Review
- Tau Stabilizes Chromatin Compaction.Frontiers in cell and developmental biology · 2021Article
- Article
- Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.PloS one · 2015Article
- Distinctive patterns of epigenetic marks are associated with promoter regions of mouse LINE-1 and LTR retrotransposons.Mobile DNA · 2013Article
- The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.The Journal of biological chemistry · 2011Article
- Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.Cancer research · 2008Article
- The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast.Molecular genetics and genomics : MGG · 2005Article
- The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin.Genes & development · 2005Article
- The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells.Nucleic acids research · 2005Article
- Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.Nucleic acids research · 2005Article
- Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophy.Chromosoma · 2004Article
- Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock.Molecular biology of the cell · 2004Article
- Centromeric chromatin pliability and memory at a human neocentromere.The EMBO journal · 2003Article
- Cell cycle-dependent and lysine residue-specific dynamic changes of histone H4 acetylation in barley.Plant molecular biology · 2002Article
- Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription.Nucleic acids research · 2001Article
- Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The pattern of histone H4 acetylation in different genomic regions has been investigated by immunoprecipitating oligonucleosomes from a human lymphoblastoid cell line with antibodies to H4 acetylated at lysines 5, 8, 12 or 16. DNA from antibody-bound or unbound chromatin was assayed by slot blotting. Pol I and pol II transcribed genes located in euchromatin were shown to have levels of H4 acetylation at lysines 5, 8 and 12 equivalent to those in input chromatin, but to be slightly enriched in H4 acetylated at lysine 16. In no case did the acetylation level correlate with actual or potential transcriptional activity. All acetylated histone H4 isoforms were depleted in non-coding, simple repeat DNA in heterochromatin, though the extent of depletion varied with the type of heterochromatin and with the isoform. Two single copy genes that map within or adjacent to blocks of paracentric heterochromatin are depleted in H4 acetylated at lysines 5, 8 and 12, but not 16. Consensus sequences of repetitive elements of the Alu family (SINES, enriched in R bands) were associated with H4 that was more highly acetylated at all four lysines than input chromatin, while H4 associated with Kpn I elements (LINES, enriched in G bands) was significantly underacetylated.
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