ArticleBritish journal of cancer1998
Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 97 citations in OpenAlex.
- Genomic features of mediastinal germ cell tumors: a narrative review.Mediastinum (Hong Kong, China) · 2022Review
- Review
- Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies.Scientific reports · 2020Article
- Genomic landscape of platinum resistant and sensitive testicular cancers.Nature communications · 2020Article
- Pediatric Germ Cell Tumors: A Developmental Perspective.Advances in urology · 2018Review
- Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.Genome research · 2016Article
- The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.Nature reviews. Urology · 2016Review
- Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.Nature communications · 2015Article
- Genomic screening of testicular germ cell tumors from monozygotic twins.Orphanet journal of rare diseases · 2014Article
- α-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis.Molecular cancer research : MCR · 2012Article
- Epigenetic: a molecular link between testicular cancer and environmental exposures.Frontiers in endocrinology · 2012Article
- Testicular germ cell tumours: predisposition genes and the male germ cell niche.Nature reviews. Cancer · 2011Review
- Zebrafish models of germ cell tumor.Methods in cell biology · 2011Article
- Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations.BMC genomics · 2010Article
- Lin28 promotes transformation and is associated with advanced human malignancies.Nature genetics · 2009Article
- Genetic variants in the 8q24 locus and risk of testicular germ cell tumors.Human genetics · 2008Article
- Genomic copy number and expression patterns in testicular germ cell tumours.British journal of cancer · 2007Article
- Malignant germ cell tumours of childhood: new associations of genomic imbalance.British journal of cancer · 2007Article
- Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors.Journal of cancer research and clinical oncology · 2006Article
- Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers.BMC cancer · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of adult testicular germ cell tumours consisting of eight seminomas, 14 non-seminomas (including two cell lines) and two combined tumours was analysed by comparative genomic hybridization and, in some cases, by interphase fluorescence in situ hybridization. The gain of 12p was identified in all cases and additional material from chromosomes 7 and 8 was found in over 70% of cases, in keeping with previous analyses. Other consistent regions of gain included 1q24-q31 (50%), 2p16-pter (41%), 2q22-q32 (45%) and Xq11-q21 (50%). The loss of 1p32-p36 (36%), 9q31-qter (36%), 11q14-qter (50%), 16p (36%) and 18p (45%) and the loss of material from chromosomes 4 and 5 (50% and 36% respectively) were also found in all histological subtypes. The loss of 1p material was confirmed in four cases by interphase FISH analysis and shown, with one exception, not to involve the loss of the D1Z2 locus at 1p36.3, which is commonly deleted in paediatric germ cell tumours. An association between gain of 6q21-q24 with cases resistant to chemotherapy (P < 0.01) was observed. In addition, loss of chromosome 19 and 22 material and gain of 5q14-q23, 6q21-q24 and 13q were found at a significantly lower frequency in seminoma than non-seminoma. These regions may contain genes involved in the divergent development of seminoma and non-seminoma.
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