ReviewMolecular neurobiology1997
Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism.
Review in Molecular neurobiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 98 citations in OpenAlex.
- Evidence-Based Theory for Integrated Genome Regulation of Ontogeny--An Unprecedented Role of Nuclear FGFR1 Signaling.Journal of cellular physiology · 2016Review
- Article
- Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.EMBO molecular medicine · 2014Article
- NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS).PloS one · 2013Article
- Article
- FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation.Histochemistry and cell biology · 2011Article
- The increase in retinal cells proliferation induced by FGF2 is mediated by tyrosine and PI3 kinases.Neurochemical research · 2008Article
- Factors controlling fibroblast growth factor receptor-1's cytoplasmic trafficking and its regulation as revealed by FRAP analysis.Molecular biology of the cell · 2006Article
- Dual regulation of calcium oscillation in astrocytes by growth factors and pro-inflammatory cytokines via the mitogen-activated protein kinase cascade.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors.Molecular biology of the cell · 2001Article
- Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression.The American journal of pathology · 1999Article
- Import(ance) of growth factors in(to) the nucleus.The Journal of cell biology · 1999Review
- Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo.Gene therapy · 1999Article
- Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals.Molecular biology of the cell · 1999Article
- Transcriptional regulation of fibroblast growth factor-2 expression in human astrocytes: implications for cell plasticity.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This article discusses a novel intracrine mechanism of growth-factor action in the nervous system whereby fibroblast growth factor-2 (FGF-2) and its receptor accumulate in the cell nucleus and act as mediators in the control of cell growth and proliferation. In human and rat brain the levels and subcellular localization of FGF-2 differ between quiescent and reactive astrocytes. Quiescent cells express a low level of FGF-2, which is located predominantly within the cytoplasm. In reactive astrocytes, the expression of FGF-2 increases and the proteins are found in both the cytoplasm and nucleus. In glioma tumors, FGF-2 is overexpressed in the nuclei of neoplastic cells. Similar changes in FGF-2 expression and localization are found in vitro. The nuclear accumulation of FGF-2 reflects a transient activation of the FGF-2 gene by potentially novel transactivating factors interacting with an upstream regulatory promoter region. In parallel with FGF-2, the nuclei of astrocytes contain the high-affinity FGF-2 receptor, FGFR1. Nuclear FGFR1 is full length, retains kinase activity, and is localized within the nuclear interior in association with the nuclear matrix. Transfection of either FGF-2 or FGFR1 into cells that do not normally express these proteins results in their nuclear accumulation and concomitant increases in cell proliferation. A similar regulation of nuclear FGF-2 and FGFR1 is observed in neural crestderived adrenal medullary cells and of FGF-2 in the nuclei of cerebellar neurons. Thus, the regulation of the nuclear content of FGF-2 and FGFR1 could serve as a novel mechanism controlling growth and proliferation of glial and neuronal cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.